ANALYSIS OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 INTEGRASE MUTANTS

被引：59

作者：

ANSARILARI, MA ^{[1
]}

DONEHOWER, LA ^{[1
]}

GIBBS, RA ^{[1
]}

机构：

[1] BAYLOR COLL MED,DIV MOLEC VIROL,HOUSTON,TX 77030

来源：

VIROLOGY | 1995年 / 211卷 / 01期

关键词：

D O I：

10.1006/viro.1995.1412

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The human immunodeficiency virus type-1 (HIV-1) integrase protein (IN) mediates the insertion of linear double-stranded viral DNA into the host genome. Mutations in IN can have different effects on the virus life cycle. In this study, Gag-Pot polyprotein processing, Tat synthesis, and viral replication were investigated in integrase-defective HIV-1 mutants. In the absence of IN synthesis, the Gag-Pol polyprotein stability, packaging, and/or processing was reduced. There was limited expression of Tat observed in IN mutants, but no viral replication. (C) 1995 Academic Press, Inc.

引用

页码：332 / 335

页数：4

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