Treatment de-escalation for HPV-driven oropharyngeal cancer: Where do we stand?

被引：141

作者：

Mirghani, Haitham ^{[1
]}

Blanchard, Pierre ^{[2
]}

机构：

[1] Gustave Roussy Canc Campus, Dept Head & Neck Oncol, 114 Rue Edouard Vaillant, Villejuif, France

[2] Gustave Roussy Canc Campus, Dept Radiat Oncol, 114 Rue Edouard Vaillant, Villejuif, France

来源：

CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY | 2018年 / 8卷

关键词：

Human papillomavirus (HPV); Oropharynx/oropharyngeal; Cancer/neoplasm; Treatment de-escalation/de-intensification;

D O I：

10.1016/j.ctro.2017.10.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

HPV-driven oropharyngeal cancers have significantly better survival rates than tobacco and alcohol induced head and neck cancers. As HPV-positive patients are younger, healthier and far more likely to survive their disease, long-term treatment side effects are becoming a major issue. This has led the scientific and medical community to reassess the current treatment protocols in order to develop less toxic strategies while maintaining good oncological outcomes. In this article, we discuss the ongoing treatment de-escalation trials and highlight the issues raised by these studies. (C) 2017 The Authors. Published by Elsevier Ireland Ltd on behalf of European Society for Radiotherapy and Oncology.

引用

页码：4 / 11

页数：8

共 53 条

[1] Efficacy of selective neck dissection: A review of 503 cases of elective and therapeutic treatment of the neck in Squamous cell carcinoma of the upper aerodigestive tract [J].

Ambrosch, P ;

Kron, M ;

Pradier, O ;

Steiner, W .

OTOLARYNGOLOGY-HEAD AND NECK SURGERY, 2001, 124 (02) :180-187

[2] A randomized phase III trial (RTOG 0522) of concurrent accelerated radiation plus cisplatin with or without cetuximab for stage III-IV head and neck squamous cell carcinomas (HNC). [J].

Ang, K. K. ;

Zhang, Q. E. ;

Rosenthal, D. I. ;

Nguyen-Tan, P. ;

Sherman, E. J. ;

Weber, R. S. ;

Galvin, J. M. ;

Schwartz, D. L. ;

El-Naggar, A. K. ;

Gillison, M. L. ;

Jordan, R. ;

List, M. A. ;

Konski, A. A. ;

Thorstad, W. L. ;

Trotti, A. ;

Beitler, J. J. ;

Garden, A. S. ;

Spanos, W. J. ;

Yom, S. S. ;

Axelrod, R. S. .

JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (15)

[3] Human Papillomavirus and Survival of Patients with Oropharyngeal Cancer [J].

Ang, K. Kian ;

Harris, Jonathan ;

Wheeler, Richard ;

Weber, Randal ;

Rosenthal, David I. ;

Nguyen-Tan, Phuc Felix ;

Westra, William H. ;

Chung, Christine H. ;

Jordan, Richard C. ;

Lu, Charles ;

Kim, Harold ;

Axelrod, Rita ;

Silverman, C. Craig ;

Redmond, Kevin P. ;

Gillison, Maura L. .

NEW ENGLAND JOURNAL OF MEDICINE, 2010, 363 (01) :24-35

[4] Toward a model-based patient selection strategy for proton therapy: External validation of photon-derived normal tissue complication probability models in a head and neck proton therapy cohort [J].

Blanchard, Pierre ;

Wong, Andrew J. ;

Gunn, G. Brandon ;

Garden, Adam S. ;

Mohamed, Abdallah S. R. ;

Rosenthal, David I. ;

Crutison, Joseph ;

Wu, Richard ;

Zhang, Xiaodong ;

Zhu, X. Ronald ;

Mohan, Radhe ;

Amin, Mayankkumar V. ;

Fuller, C. David ;

Frank, Steven J. .

RADIOTHERAPY AND ONCOLOGY, 2016, 121 (03) :381-386

[5] Assessing head and neck cancer patient preferences and expectations: A systematic review [J].

Blanchard, Pierre ;

Volk, Robert J. ;

Ringash, Jolie ;

Peterson, Susan K. ;

Hutcheson, Katherine A. ;

Frank, Steven J. .

ORAL ONCOLOGY, 2016, 62 :44-53

[6] Intensity-modulated proton beam therapy (IMPT) versus intensity-modulated photon therapy (IMRT) for patients with oropharynx cancer - A case matched analysis [J].

Blanchard, Pierre ;

Garden, Adam S. ;

Gunn, G. Brandon ;

Rosenthal, David I. ;

Morrison, William H. ;

Hernandez, Mike ;

Crutison, Joseph ;

Lee, Jack J. ;

Ye, Rong ;

Fuller, C. David ;

Mohamed, Abdallah S. R. ;

Hutcheson, Kate A. ;

Holliday, Emma B. ;

Thaker, Nikhil G. ;

Sturgis, Erich M. ;

Kies, Merrill S. ;

Zhu, X. Ronald ;

Mohan, Radhe ;

Frank, Steven J. .

RADIOTHERAPY AND ONCOLOGY, 2016, 120 (01) :48-55

[7] Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck [J].

Bonner, JA ;

Harari, PM ;

Giralt, J ;

Azarnia, N ;

Shin, DM ;

Cohen, RB ;

Jones, CU ;

Sur, R ;

Raben, D ;

Jassem, J ;

Ove, R ;

Kies, MS ;

Baselga, J ;

Youssoufian, H ;

Amellal, N ;

Rowinsky, EK ;

Ang, KK .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 354 (06) :567-578

[8] A review of human carcinogens-Part B: biological agents [J].

Bouvard, Veronique ;

Baan, Robert ;

Straif, Kurt ;

Grosse, Yann ;

Secretan, Beatrice ;

El Ghissassi, Fatiha ;

Benbrahim-Tallaa, Lamia ;

Guha, Neela ;

Freeman, Crystal ;

Galichet, Laurent ;

Cogliano, Vincent .

LANCET ONCOLOGY, 2009, 10 (04) :321-322

[9] Patient preferences for oropharyngeal cancer treatment de-escalation [J].

Brotherston, Drew C. ;

Poon, Ian ;

Le, Tuyen ;

Leung, Martin ;

Kiss, Alex ;

Ringash, Jolie ;

Balogh, Judith ;

Lee, Justin ;

Wright, James R. .

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 2013, 35 (02) :151-159

[10] Subgroup Analysis According to Human Papillomavirus Status and Tumor Site of a Randomized Phase II Trial Comparing Cetuximab and Cisplatin Combined With Radiation Therapy for Locally Advanced Head and Neck Cancer [J].

Buglione, Michela ;

Maddalo, Marta ;

Corvo, Renzo ;

Pirtoli, Luigi ;

Paiar, Fabiola ;

Lastrucci, Luciana ;

Stefanacci, Marco ;

Belgioia, Liliana ;

Crociani, Monica ;

Vecchio, Stefania ;

Bonomo, Pierluigi ;

Bertocci, Silvia ;

Borghetti, Paolo ;

Pasinetti, Nadia ;

Triggiani, Luca ;

Costa, Loredana ;

Tonoli, Sandro ;

Grisanti, Salvatore ;

Magrini, Stefano Maria .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2017, 97 (03) :462-472

← 1 2 3 4 5 6 →