LACTATE-DEHYDROGENASE ACTIVITY AND ITS ISOENZYMES IN SERUM AND SYNOVIAL-FLUID OF PATIENTS WITH RHEUMATOID-ARTHRITIS AND OSTEOARTHRITIS

被引:0
作者
PEJOVIC, M
STANKOVIC, A
MITROVIC, DR
机构
[1] HOP LARIBOISIERE, INSERM, U349, 6 RUE GUY PATIN, F-75475 PARIS 10, FRANCE
[2] UNIV NIS, INST RHEUMATOL, NISH, YUGOSLAVIA
[3] UNIV NIS, SCH MED, NISH, YUGOSLAVIA
关键词
LACTATE DEHYDROGENASE; SERUM; SYNOVIAL FLUID; OSTEOARTHRITIS; RHEUMATOID ARTHRITIS;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
By determining the total activity of total lactate dehydrogenase (LDH-T) and its isoenzymes in serum and synovial fluid (SF) of patients with rheumatoid arthritis (RA) and osteoarthritis (OA) we demonstrated in RA serum increased (p < 0.02) activity of hepatic LDH (LDH-H) and a shift of the LDH isoenzymatic profile towards the M forms; in rheumatoid SF increased (p < 0.001) activity of the total LDH-T and LDH-H which makes possible the use of these markers of inflammation in assessing RA activity. Values for LDH-T and LDH-H of 400-700 U/l and 300-500 U/l, respectively, correspond to moderate disease activity, while values exceeding 750 U/l and 550 U/l, respectively, correspond to high RA activity. The anerobic isoenzymatic distribution of LDH in rheumatoid SF results in a significant (p < 0.001) decrease in LDH1 and LDH2 and an increase (p < 0.001) in LDH4 and LDH5.
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页码:529 / 533
页数:5
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