EFFICACY OF AMOXYCILLIN CLAVULANIC ACID IN EXPERIMENTAL STAPHYLOCOCCUS-AUREUS ENDOCARDITIS IN THE RAT

被引：7

作者：

CATHERALL, EJ

IRWIN, R

MIZEN, LW

机构：

[1] SmithKline Beecham Pharmaceuticals, Betchworth Surrey RH3 7AJ, Brockham Park

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 1991年 / 27卷 / 01期

关键词：

D O I：

10.1093/jac/27.1.117

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The efficacy of amoxycillin/clavulanic acid was compared with that of flucloxacillin, vancomycin and amoxycillin in an experimental model of Staphylococcus aureus endocarditis. Doses of the antibiotics were selected to produce peak concentrations in rat serum similar to those achievable in man after administration of parenteral therapeutic doses. Amoxycillin/clavulanic acid was more effective than amoxycillin alone against endocarditis caused by β-lactamase producing strains of Staph. aureus, illustrating the β-lactamase inhibitory activity of clavulanic acid in vivo. Amoxycillin/clavulanic acid was as effective as flucloxacillin in these infections whereas vancomycin was generally less active. These results illustrate the clinical potential of amoxycillin/clavulanic acid in the prophylaxis, or in the therapy of severe staphylococcal infections. © 1991 The British Society for Antimicrobial Chemotherapy.

引用

页码：117 / 126

页数：10

共 33 条

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