NEW LONG-ACTING INJECTABLE MICROCAPSULE CONTRACEPTIVE SYSTEM

被引:70
作者
BECK, LR
COWSAR, DR
LEWIS, DH
GIBSON, JW
FLOWERS, CE
机构
[1] UNIV ALABAMA,DEPT OBSTET & GYNECOL,REPROD BIOL & ENDOCRINOL LAB,BIRMINGHAM,AL 35294
[2] SO RES INST,BIRMINGHAM,AL 35205
关键词
D O I
10.1016/0002-9378(79)90717-8
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
A new long-acting, injectable contraceptive which provides continuous controlled release of the steroid norethisterone (NET) for a precise period of 6 months following a single intramuscular injection is described. The prototype system consists of microcapsules made of the biodegradable polymer d, l-polylactic acid, in which micronized crystals of NET are homogeneously dispersed. NET is slowly released from the microcapsules following intramuscular injection at a rate of 0.90 μg NET/day/mg of microcapsule by diffusion of the steroid from the polymer matrix. Three different doses of a standard preparation of microcapsules were tested in normally cycling female baboons (4 to 5 baboons/group). Following injection of either 300, 200, or 100 mg of microcapsules containing 75, 50, or 25 mg of NET, blood samples were collected at selected intervals and analyzed for NET, estrogen, and progesterone by radioimmunoassay. All three doses provided continuous NET release for 6 months following injection. The NET serum profiles for the different doses are parallel, and ovulation was inhibited in all baboons for 6 months following treatment. © 1979.
引用
收藏
页码:419 / 426
页数:8
相关论文
共 9 条
[1]   INJECTABLE SUSTAINED-RELEASE FERTILITY CONTROL-SYSTEM [J].
ANDERSON, LC ;
WISE, DL ;
HOWES, JF .
CONTRACEPTION, 1976, 13 (03) :375-384
[2]   SOCIOBEHAVIORAL DETERMINANTS OF COMPLIANCE WITH HEALTH AND MEDICAL CARE RECOMMENDATIONS [J].
BECKER, MH ;
MAIMAN, LA .
MEDICAL CARE, 1975, 13 (01) :10-24
[3]  
BENAGIANO G, 1976, WHO S ADV FERTILITY, P223
[4]   FABRICATION AND TESTING OF VAGINAL CONTRACEPTIVE DEVICES DESIGNED FOR RELEASE OF PRESPECIFIED DOSE LEVELS OF STEROIDS [J].
BURTON, FG ;
SKIENS, WE ;
GORDON, NR ;
VEAL, JT ;
KALKWARF, DR ;
DUNCAN, GW .
CONTRACEPTION, 1978, 17 (03) :221-230
[5]   LARGER ANIMAL TESTING OF AN INJECTABLE SUSTAINED-RELEASE FERTILITY-CONTROL SYSTEM [J].
GRESSER, JD ;
WISE, DL ;
BECK, LE ;
HOWES, JF .
CONTRACEPTION, 1978, 17 (03) :253-266
[6]   RADIOIMMUNOASSAY OF NORETHINDRONE - PERIPHERAL PLASMA-LEVELS AFTER ORAL-ADMINISTRATION TO HUMANS AND RHESUS-MONKEYS [J].
NYGREN, KG ;
LINDBERG, P ;
MARTINSSON, K ;
BOSU, WTK ;
JOHANSSON, ED .
CONTRACEPTION, 1974, 9 (03) :265-278
[7]  
PHARRISS BB, 1974, FERTIL STERIL, V25, P913
[8]   ACCEPTABILITY OF LONG-TERM CONTRACEPTIVE STEROID ADMINISTRATION IN HUMANS BY SUBCUTANEOUS SILASTIC CAPSULES [J].
TATUM, HJ ;
COUTINHO, EM ;
FILHO, JA ;
SANTANNA, AR .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1969, 105 (07) :1139-&
[9]  
1977, CONTRACEPTION, V15, P513