Altered Cognitive Development in the Siblings of Individuals With Schizophrenia

被引：10

作者：

Barch, Deanna M. ^{[1
,2
]}

Cohen, Rachel ^{[1
,3
]}

Csernansky, John G. ^{[4
]}

机构：

[1] Washington Univ, Dept Psychol, Dept Psychiat, Campus Box 1125,One Brookings Dr, St Louis, MO 63130 USA

[2] Washington Univ, Dept Radiol, St Louis, MO USA

[3] Northwestern Univ, Dept Psychol, Evanston, IL 60208 USA

[4] Northwestern Univ, Dept Psychiat, Evanston, IL 60208 USA

来源：

CLINICAL PSYCHOLOGICAL SCIENCE | 2014年 / 2卷 / 02期

关键词：

schizophrenia; cognition and emotion; developmental psychopathology;

D O I：

10.1177/2167702613496244

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

Our goal in the current study was to further investigate the late neurodevelopmental hypothesis of schizophrenia by examining cross-sectional, age-related changes in cognitive function among young adult (a) siblings of individuals with schizophrenia (n = 66), (b) healthy control subjects (n = 77), and (c) the siblings of healthy control subjects (n = 77). All subjects participated in a battery of tasks in four domains: verbal IQ, working memory, episodic memory, and executive function. We found significant group differences in the relationships between age and performance in working memory and episodic memory, with similar patterns for executive function and verbal IQ. The siblings of individuals with schizophrenia showed impaired performance in working memory, episodic memory, and executive function. In addition, healthy control subjects and their siblings showed age-related improvements in all four cognitive domains, whereas the siblings of individuals with schizophrenia showed this result for verbal IQ only.

引用

页码：138 / 151

页数：14

共 84 条

[1] American Psychiatric Association (APA), 1994, AM PSYCHIATR ASSOC, V4th
[2] Andreasen N. C., 1983, CITY
[3] Andreasen NC, 1983, SCALE ASSESSMENT NEG
[4] Neurocognitive functioning and schizophrenia spectrum disorders can be independent expressions of familial liability for schizophrenia in community control children: the UCLA family study
Asarnow, RF
Nuechterlein, KH
Asamen, J
Fogelson, D
Subotnik, KL
Zaucha, K
Guthrie, D
[J]. SCHIZOPHRENIA RESEARCH, 2002, 54 (1-2) : 111 - 120
[5] The cognitive neuroscience of schizophrenia
Barch, Deanna M.
[J]. ANNUAL REVIEW OF CLINICAL PSYCHOLOGY, 2005, 1 : 321 - 353
[6] Context-processing deficits in schizophrenia: Diagnostic specificity, 4-week course, and relationships to clinical symptoms
Barch, DM
Carter, CS
MacDonald, AW
Braver, TS
Cohen, JD
[J]. JOURNAL OF ABNORMAL PSYCHOLOGY, 2003, 112 (01) : 132 - 143
[7] Working and long-term memory deficits in Schizophrenia: Is there a common prefrontal mechanism?
Barch, DM
Csernansky, JG
Conturo, T
Snyder, AZ
[J]. JOURNAL OF ABNORMAL PSYCHOLOGY, 2002, 111 (03) : 478 - 494
[8] Schizophrenia: Breakdown in the well-regulated lifelong development and
Bartzokis, G
[J]. NEUROPSYCHOPHARMACOLOGY, 2002, 27 (04) : 672 - 683
[9] DIFFERENTIAL BEHAVIORAL EFFECTS IN FRONTAL LOBE DISEASE
BENTON, AL
[J]. NEUROPSYCHOLOGIA, 1968, 6 (01) : 53 - &
[10] Berg E. A, 1948, J GEN PSYCHOL, V39

← 1 2 3 4 5 6 7 8 9 →