LACK OF ASSOCIATION OF HUMAN POLYOMAVIRUSES WITH HUMAN BRAIN-TUMORS

被引：47
作者：
ARTHUR, RR
GROSSMAN, SA
RONNETT, BM
BIGNER, SH
VOGELSTEIN, B
SHAH, KV
机构：
[1] JOHNS HOPKINS UNIV, SCH HYG & PUBL HLTH, DEPT IMMUNOL & INFECT DIS, BALTIMORE, MD 21205 USA
[2] JOHNS HOPKINS UNIV, SCH MED, DEPT PATHOL, BALTIMORE, MD 21205 USA
[3] JOHNS HOPKINS UNIV, CTR ONCOL, BALTIMORE, MD 21205 USA
来源：
JOURNAL OF NEURO-ONCOLOGY | 1994年 / 20卷 / 01期
关键词：
POLYOMAVIRUSES; BKV; JCV; BRAIN TUMORS; POLYMERASE CHAIN REACTION; PCR;
D O I：
10.1007/BF01057961
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Brain tumors, primarily glioblastoma multiforme, were examined for the presence of BKV DNA. DNAs extracted from 33 fresh-frozen tumors and from an additional 47 paraffin-embedded tumor tissues were tested for BKV sequences using two different primer pairs. One primer pair amplified highly conserved sequences in the early region coding for BKV and JCV T antigens. The other primer pair amplified the regulatory region of BKV-IR, a variant previously associated with human brain tumors. None of the tumors were positive for BKV or JCV DNA.
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页码：55 / 58
页数：4
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