AGE-ASSOCIATED DECREASES IN PROSTAGLANDIN CONTENTS IN HUMAN GASTRIC-MUCOSA

被引：39

作者：

GOTO, H ^{[1
]}

SUGIYAMA, S ^{[1
]}

OHARA, A ^{[1
]}

HOSHINO, H ^{[1
]}

HAMAJIMA, E ^{[1
]}

KANAMORI, S ^{[1
]}

TSUKAMOTO, Y ^{[1
]}

OZAWA, T ^{[1
]}

机构：

[1] NAGOYA UNIV,FAC MED,DEPT BIOMED CHEM,SHOWA KU,NAGOYA,AICHI 466,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 186卷 / 03期

关键词：

D O I：

10.1016/S0006-291X(05)81568-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This study was designed to clarify effects of ageing on human gastric mucosal prostaglandin (PG) contents. Forty examinees were divided into 5 age groups of 8 persons each, as follows: age under 40, age 40-49, age 50-59, age 60-69, and age over 70. PG contents in human gastric mucosa were measured by microcolumn high performance liquid chromatography (HPLC) with helium/cadmium laser induced fluorescence detection using biopsy samples obtained by endoscopy. The contents of 6-keto-PGF1α, PGF2α, PGE2, and PGD2 in the under 40 group were 638±39, 97±16, 468±68, 497±86 (pg/mg tissue), respectively. No significant differences in PG contents among groups aged under 70 were observed. In contrast, significantly low PG contents in the over 70 group were observed, i.e., the contents of 6-keto-PGF1α, PGF2α, PGE2, and PGD2 were 311±58, 36±8, 196±48, 171±40, respectively, and their contents were significantly lower than those in other age groups. In conclusion, gastric mucosal PG contents decrease significantly in over 70 years-old and this might be a contributing factor in the pathogenesis of gastric ulcers in elderly people. © 1992 Academic Press, Inc.

引用

页码：1443 / 1448

页数：6

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