ENANTIOSELECTIVE HYDROLYSIS OF HYDROPHOBIC AMINO-ACID DERIVATIVES BY LIPASES

被引：10

作者：

CHIOU, AJ ^{[1
]}

WU, SH ^{[1
]}

WANG, KT ^{[1
]}

机构：

[1] NATL TAIWAN UNIV, GRAD INST BIOCHEM SCI, POB 23-106, TAIPEI, TAIWAN

来源：

BIOTECHNOLOGY LETTERS | 1992年 / 14卷 / 06期

关键词：

D O I：

10.1007/BF01023167

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Microbial lipases preferentially cleave the L-isomers of N-benzyloxycarbonyl(Z)-hydrophobic D,L-amino acid methyl esters which is the same as that of subtilisin. This implies that lipases and proteases may share the same ancestor in the evolutionary point and lipases can be practically applied to resolve racemic hydrophobic amino acid derivatives.

引用

页码：461 / 464

页数：4

共 11 条

[1] A SERINE PROTEASE TRIAD FORMS THE CATALYTIC CENTER OF A TRIACYLGLYCEROL LIPASE [J].

BRADY, L ;

BRZOZOWSKI, AM ;

DEREWENDA, ZS ;

DODSON, E ;

DODSON, G ;

TOLLEY, S ;

TURKENBURG, JP ;

CHRISTIANSEN, L ;

HUGEJENSEN, B ;

NORSKOV, L ;

THIM, L ;

MENGE, U .

NATURE, 1990, 343 (6260) :767-770

[2] QUANTITATIVE-ANALYSES OF BIOCHEMICAL KINETIC RESOLUTIONS OF ENANTIOMERS [J].

CHEN, CS ;

FUJIMOTO, Y ;

GIRDAUKAS, G ;

SIH, CJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1982, 104 (25) :7294-7299

[3] RESOLUTION OF RACEMIC MIXTURES VIA LIPASE CATALYSIS IN ORGANIC-SOLVENTS [J].

KIRCHNER, G ;

SCOLLAR, MP ;

KLIBANOV, AM .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1985, 107 (24) :7072-7076

[4] STEREOSELECTIVE ESTERIFICATION OF DL-MENTHOL BY POLYURETHANE-ENTRAPPED LIPASE IN ORGANIC-SOLVENT [J].

KOSHIRO, S ;

SONOMOTO, K ;

TANAKA, A ;

FUKUI, S .

JOURNAL OF BIOTECHNOLOGY, 1985, 2 (01) :47-57

[5] LIPASE-CATALYZED HYDROLYSIS AS A ROUTE TO ESTERS OF CHIRAL EPOXY ALCOHOLS [J].

LADNER, WE ;

WHITESIDES, GM .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1984, 106 (23) :7250-7251

[6] LIPASE-CATALYZED ESTER FORMATION IN ORGANIC-SOLVENTS AN EASY PREPARATIVE RESOLUTION OF ALPHA-SUBSTITUTED CYCLOHEXANOLS [J].

LANGRAND, G ;

SECCHI, M ;

BUONO, G ;

BARATTI, J ;

TRIANTAPHYLIDES, C .

TETRAHEDRON LETTERS, 1985, 26 (15) :1857-1860

[7] OPTICAL RESOLUTION OF UNUSUAL AMINO-ACIDS BY LIPASE-CATALYZED HYDROLYSIS [J].

MIYAZAWA, T ;

TAKITANI, T ;

UEJI, S ;

YAMADA, T ;

KUWATA, S .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1988, (17) :1214-1215

[8] SER-HIS-GLU TRIAD FORMS THE CATALYTIC SITE OF THE LIPASE FROM GEOTRICHUM-CANDIDUM [J].

SCHRAG, JD ;

LI, Y ;

WU, S ;

CYGLER, M .

NATURE, 1991, 351 (6329) :761-764

[9]

SIH CJ, 1989, TOP STEREOCHEM, V19, P63

[10] KINETIC RESOLUTIONS OF ALIPHATIC-ALCOHOLS WITH A FUNGAL LIPASE FROM MUCOR-MIEHEI [J].

SONNET, PE .

JOURNAL OF ORGANIC CHEMISTRY, 1987, 52 (15) :3477-3479

← 1 2 →