CROSS-CONJUGATED AND PSEUDO-CROSS-CONJUGATED MESOMERIC BETAINES .18. BICYCLIC MESOIONIC PYRIMIDINES WITH CARDIOVASCULAR ACTIVITY

被引：19

作者：

KAPPE, CO

KAPPE, T

机构：

来源：

ARCHIV DER PHARMAZIE | 1991年 / 324卷 / 11期

关键词：

D O I：

10.1002/ardp.2503241108

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Reaction of alpha-Anilino-azines 1a-i with activated malonates (magic malonates) 2a-e leads to bicyclic mesoionic systems 3-7. Out of these, pyrido[1,2-a]pyrimidines 3b,d are active as cardiotonics, whereas pyrimido[1,2-a]pyrimidines 4a-g show significant anti-anginal and anti-hypertensive activity.

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页码：863 / 866

页数：4

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