INHIBITORY ACTIONS OF PROSTAGLANDIN-E1 ON NONADRENERGIC NONCHOLINERGIC CONTRACTION IN GUINEA-PIG BRONCHI

被引：21

作者：

AIKAWA, T ^{[1
]}

SEKIZAWA, K ^{[1
]}

ITABASHI, S ^{[1
]}

SASAKI, H ^{[1
]}

TAKISHIMA, T ^{[1
]}

机构：

[1] TOHOKU UNIV,SCH MED,DEPT INTERNAL MED 1,SENDAI,MIYAGI 980,JAPAN

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 1990年 / 101卷 / 01期

关键词：

D O I：

10.1111/j.1476-5381.1990.tb12080.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We have investigated the effect of prostaglandin E1 (PGE1) on non-adrenergic, non-cholinergic (NANC) contraction in guinea-pig bronchial strips. PGE1 (10 nM to 10 μM) did not alter baseline tension but reduced NANC contractions induced by electrical field stimulation (EFS) in a concentration-dependent fashion (-log EC50 was 6.60 ± 0.10 M and maximum inhibition was 88.7 ± 2.9%). PGE1 (>0.3 μM) also reduced the contraction induced by substance P (1 μM). Removal of epithelium did not alter the effects of PGE1 on NANC contraction. These results suggest that PGE1 exerts both pre- and post-junctional inhibitory actions on NANC contraction.

引用

页码：13 / 14

页数：2

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