EFFECT OF NOREPINEPHRINE ON INVITRO HISTAMINE-RELEASE FROM RAT MAST-CELLS

被引：14

作者：

ALM, PE ^{[1
]}

BLOOM, GD ^{[1
]}

机构：

[1] UNIV UMEA,DEPT HISTOL,S-90187 UMEA,SWEDEN

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY | 1979年 / 60卷 / 01期

关键词：

D O I：

10.1159/000232323

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

The effect of norepinephrine on compound 48/80-induced histamine release from rat peritoneal mast cells, was studied in an in vitro system. It was found that norepinephrine, within the concentration range 10-5-10-3M, exerts a significant, dose-related, repressive effect. This effect is greatly potentiated by the β-antagonist practolol (10-3M), throughout the concentration range of 10-11-10-3M norepinephrine. Meth-oxyamine, a selective α-adrenergic agonist, also represses histamine release in a dose-dependent manner; however, it is not as potent as norepinephrine. The present results would seem to suggest that the repressive effect on histamine release, observed within a low concentration range of norepinephrine, may be due to α-adrenoceptor mechanisms. © 1979 S. Karger AG, Basel.

引用

页码：60 / 67

页数：8

共 17 条

[11] EFFECTS OF ADRENOTROPIC DRUGS ON THE RELEASE OF HISTAMINE IN THE ANAPHYLACTIC REACTION OF THE ISOLATED GUINEA PIG HEART [J].