Inflammatory myofibroblastic tumors (IMT) are uncommon neoplasms of the lung in adults. They constitute less than 1% of all lung neoplasms and usually present as parenchymal masses. Diagnosis requires a high index of suspicion. They are characterized by spindle-shaped tumor cells (fibroblasts/myofibroblasts) in a background of lymphoplasmacytic infiltrate. About 50% of the tumors harbor an ALK gene rearrangement. They have to be differentiated from inflammatory pseudotumors (IPT), which show increased number of IgG4 plasma cells on immunostaining and are negative for anaplastic lymphoma kinase (ALK) protein. Herein, we present a case of a 28-year old female who presented with hemoptysis and was diagnosed with an IMT of lung in the first trimester of pregnancy. We have not only reviewed the occurrence of IMT during pregnancy but also discuss the management options for IMT during pregnancy.
机构:
Harvard Med Sch, Surg, Beth Israel Deaconess Med Ctr, Boston, MA USA
Methodist Hlth Syst, Surg Oncol, San Antonio, TX 78229 USAHarvard Med Sch, Surg, Beth Israel Deaconess Med Ctr, Boston, MA USA
Flores, Rene
De La Garza, Henriette
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Boston Univ Sch Med, Dermatol, Boston, MA USAHarvard Med Sch, Surg, Beth Israel Deaconess Med Ctr, Boston, MA USA
De La Garza, Henriette
Santillan-Gomez, Alfredo A.
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Methodist Hlth Syst, Surg Oncol, San Antonio, TX 78229 USAHarvard Med Sch, Surg, Beth Israel Deaconess Med Ctr, Boston, MA USA
机构:
China Med Univ, Coll Chinese Med, Sch Chinese Med, China Med Univ Hosp,Dept Internal Med, Taichung, TaiwanChina Med Univ, Coll Chinese Med, Sch Chinese Med, China Med Univ Hosp,Dept Internal Med, Taichung, Taiwan
Wang, Tzu-Yuan
Chou, Jen-Wei
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China Med Univ, Coll Chinese Med, Sch Chinese Med, China Med Univ Hosp,Dept Internal Med, Taichung, TaiwanChina Med Univ, Coll Chinese Med, Sch Chinese Med, China Med Univ Hosp,Dept Internal Med, Taichung, Taiwan