THE EFFECT OF ENDOTHELIN, NEUROPEPTIDE-Y, CALCITONIN-GENE-RELATED PEPTIDE AND SUBSTANCE-P ON NEUTROPHIL FUNCTIONS

被引：42
作者：
HAFSTROM, I
RINGERTZ, B
LUNDEBERG, T
PALMBLAD, J
机构：
[1] KAROLINSKA INST,STOCKHOLM SODER HOSP,DEPT MED,S-11883 STOCKHOLM,SWEDEN
[2] KAROLINSKA INST,DEPT PHYSIOL,S-10401 STOCKHOLM 60,SWEDEN
来源：
ACTA PHYSIOLOGICA SCANDINAVICA | 1993年 / 148卷 / 03期
关键词：
AGGREGATION; ENDOTHELIN; CALCITONIN GENE-RELATED PEPTIDE; CALCIUM; CHEMILUMINESCENCE; CHEMOTAXIS; NEUROPEPTIDE-Y; NEUTROPHILS; PMN; SUBSTANCE-P;
D O I：
10.1111/j.1748-1716.1993.tb09565.x
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Neuropeptides are putative mediators of inflammation. At physiological concentrations substance P has been shown to prime polymorphonuclear neutrophil granulocyte (PMN) chemiluminescence (CL). In the present study we show also that both endothelin and neuropeptide Y (NPY), but not calcitonin gene-related peptide (CGRP) are able to prime PMN oxidative metabolism. At similar nanomolar concentrations SP and endothelin (but not NPY) also primed formyl-methionyl-leucyl-phenylalanine (fMLP)-induced rises of cytosolic calcium. On the other hand, NPY caused a direct and dose-related increase of cytosolic calcium concentrations. None of the mentioned neuropeptides primed PMN aggregation or directly induced CL, aggregation or chemotaxis over a wide range of concentrations (1 fM-1 muM).
引用
收藏
页码：341 / 346
页数：6
相关论文
共 25 条
[1]   INFLAMMATORY EDEMA INDUCED BY SYNERGISM BETWEEN CALCITONIN GENE-RELATED PEPTIDE (CGRP) AND MEDIATORS OF INCREASED VASCULAR-PERMEABILITY [J].
BRAIN, SD ;
WILLIAMS, TJ .
BRITISH JOURNAL OF PHARMACOLOGY, 1985, 86 (04) :855-860
[2]   TIME-DEPENDENT SYNERGISTIC INTERACTIONS BETWEEN THE VASODILATOR NEUROPEPTIDE, CALCITONIN GENE-RELATED PEPTIDE (CGRP) AND MEDIATORS OF INFLAMMATION [J].
BUCKLEY, TL ;
BRAIN, SD ;
RAMPART, M ;
WILLIAMS, TJ .
BRITISH JOURNAL OF PHARMACOLOGY, 1991, 103 (02) :1515-1519
[3]   NEUROPEPTIDE-Y MOBILIZES INTRACELLULAR CA2+ AND INCREASES INOSITOL PHOSPHATE PRODUCTION IN HUMAN ERYTHROLEUKEMIA-CELLS [J].
DANIELS, AJ ;
LAZAROWSKI, ER ;
MATTHEWS, JE ;
LAPETINA, EG .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 165 (03) :1138-1144
[4]  
DASILVA JAP, 1990, J RHEUMATOL, V17, P1592
[5]  
DOCKRAY GJ, 1988, ISI ATLAS-PHARMACOL, V2, P40
[6]   POTENTIATION OF TACHYKININ-INDUCED PLASMA-PROTEIN EXTRAVASATION BY CALCITONIN GENE-RELATED PEPTIDE [J].
GAMSE, R ;
SARIA, A .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1985, 114 (01) :61-66
[7]  
HAFSTROM I, 1989, J RHEUMATOL, V16, P1033
[8]   ENDOTHELIN-1 ENHANCES SUPEROXIDE GENERATION OF HUMAN NEUTROPHILS STIMULATED BY THE CHEMOTACTIC PEPTIDE N-FORMYL-METHIONYL-LEUCYL-PHENYLALANINE [J].
ISHIDA, K ;
TAKESHIGE, K ;
MINAKAMI, S .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1990, 173 (02) :496-500
[9]   EFFECT OF SULFASALAZINE AND SULFAPYRIDINE ON NEUTROPHIL SUPEROXIDE PRODUCTION - ROLE OF CYTOSOLIC FREE CALCIUM [J].
KANERUD, L ;
HAFSTROM, I ;
RINGERTZ, B .
ANNALS OF THE RHEUMATIC DISEASES, 1990, 49 (05) :296-300
[10]   CONCENTRATION OF SUBSTANCE-P, NEUROKININ A, CALCITONIN GENE-RELATED PEPTIDE, NEUROPEPTIDE-Y AND VASOACTIVE INTESTINAL POLYPEPTIDE IN SYNOVIAL-FLUID FROM KNEE JOINTS IN PATIENTS SUFFERING FROM RHEUMATOID-ARTHRITIS [J].
LARSSON, J ;
EKBLOM, A ;
HENRIKSSON, K ;
LUNDEBERG, T ;
THEODORSSON, E .
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY, 1991, 20 (05) :326-335
123