DIRECT CHIRAL RESOLUTION OF AMINO-ACID DERIVATIVES BY CAPILLARY ELECTROPHORESIS

被引：66

作者：

OKAFO, GN ^{[1
]}

CAMILLERI, P ^{[1
]}

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT,WELWYN GARDEN CIT AL6 9AR,HERTS,ENGLAND

来源：

JOURNAL OF MICROCOLUMN SEPARATIONS | 1993年 / 5卷 / 02期

关键词：

CAPILLARY ELECTROPHORESIS; BETA-CYCLODEXTRIN; TAURODEOXYCHOLATE; AMINO ACIDS;

D O I：

10.1002/mcs.1220050210

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A mixture of sodium deoxycholate and beta-cyclodextrin has been used to resolve the enantiomers of the 1-cyano-2-substituted-benz[L]isoindole and dansyl derivatives of a variety of amino acids. The enantiomers of CBI-histidine and glutamic acid were resolved with this system unlike the case of gamma-cyclodextrin in combination with SDS reported in the literature. Dansyl derivatives have been generated in situ to provide information about the migration behavior of dansylic acid, a major by-product in the dansylation.

引用

页码：149 / 153

页数：5