INTERLEUKIN-6 - PRESENCE AND FUTURE

被引：47
作者：
BRACH, MA [1 ]
HERRMANN, F [1 ]
机构：
[1] UNIV FREIBURG, MED CTR, DEPT HEMATOL & ONCOL, HUGSTETTER STR 55, W-7800 FREIBURG, GERMANY
来源：
INTERNATIONAL JOURNAL OF CLINICAL & LABORATORY RESEARCH | 1992年 / 22卷 / 03期
关键词：
IL-6; BIOLOGIC AND CLINICAL CHARACTERISTICS;
D O I：
10.1007/BF02591414
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
This review article deals with the basic biological characteristics of the multifunctional cytokine interleukin-6 (IL-6) in man. Three central issues will be addressed more closely: the pathophysiological role of unbalanced IL-6 production in various disease states, the diagnostic usefulness of measurements of IL-6 in biological fluids, and the possible role of IL-6, IL-6 antagonists, and IL-6 derivatives as therapeutic tools in clinical medicine.
引用
收藏
页码：143 / 151
页数：9
相关论文
共 105 条
[1]   BIOLOGY OF MULTIFUNCTIONAL CYTOKINES - IL-6 AND RELATED MOLECULES (IL-1 AND TNF) [J].
AKIRA, S ;
HIRANO, T ;
TAGA, T ;
KISHIMOTO, T .
FASEB JOURNAL, 1990, 4 (11) :2860-2867
[2]  
ANDUS ST, 1991, PATHOBIOLOGY, V9, P113
[3]   RECOMBINANT HUMAN B-CELL STIMULATORY FACTOR-II (BSF-2/IFN-BETA2) REGULATES BETA-FIBRINOGEN AND ALBUMIN MESSENGER-RNA LEVELS IN FAO-9 CELLS [J].
ANDUS, T ;
GEIGER, T ;
HIRANO, T ;
NORTHOFF, H ;
GANTER, U ;
BAUER, J ;
KISHIMOTO, T ;
HEINRICH, PC .
FEBS LETTERS, 1987, 221 (01) :18-22
[4]   SERUM LEVELS OF INTERLEUKIN-6, A POTENT MYELOMA CELL-GROWTH FACTOR, AS A REFLECT OF DISEASE SEVERITY IN PLASMA-CELL DYSCRASIAS [J].
BATAILLE, R ;
JOURDAN, M ;
ZHANG, XG ;
KLEIN, B .
JOURNAL OF CLINICAL INVESTIGATION, 1989, 84 (06) :2008-2011
[5]  
BAUER J, 1988, BLOOD, V72, P1134
[6]   INTERLEUKIN-6 IN CLINICAL MEDICINE [J].
BAUER, J ;
HERRMANN, F .
ANNALS OF HEMATOLOGY, 1991, 62 (06) :203-210
[7]   INTERLEUKIN-6 AND ALPHA-2-MACROGLOBULIN INDICATE AN ACUTE-PHASE STATE IN ALZHEIMERS-DISEASE CORTICES [J].
BAUER, J ;
STRAUSS, S ;
SCHREITERGASSER, U ;
GANTER, U ;
SCHLEGEL, P ;
WITT, I ;
YOLK, B ;
BERGER, M .
FEBS LETTERS, 1991, 285 (01) :111-114
[8]   REGULATION OF INTERLEUKIN-6 RECEPTOR EXPRESSION IN HUMAN-MONOCYTES AND MONOCYTE-DERIVED MACROPHAGES - COMPARISON WITH THE EXPRESSION IN HUMAN HEPATOCYTES [J].
BAUER, J ;
BAUER, TM ;
KALB, T ;
TAGA, T ;
LENGYEL, G ;
HIRANO, T ;
KISHIMOTO, T ;
ACS, G ;
MAYER, L ;
GEROK, W .
JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 170 (05) :1537-1549
[9]   INTERLEUKIN-1-BETA INDUCES SYNTHESIS AND SECRETION OF INTERLEUKIN-6 IN HUMAN CHONDROCYTES [J].
BENDER, S ;
HAUBECK, HD ;
VANDELEUR, E ;
DUFHUES, G ;
SCHIEL, X ;
LAUWERIJNS, J ;
GREILING, H ;
HEINRICH, PC .
FEBS LETTERS, 1990, 263 (02) :321-324
[10]  
BOT FJ, 1989, BLOOD, V73, P435
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