BIOAVAILABILITY OF CHLORPROPAMIDE

被引：8

作者：

EVANS, M ^{[1
]}

GLASS, RC ^{[1
]}

MITCHARD, M ^{[1
]}

MUNDAY, BM ^{[1
]}

YATES, R ^{[1
]}

机构：

[1] UNIV BIRMINGHAM,SCH MED,DEPT CLIN PHARMACOL,BIRMINGHAM B15 2TJ,W MIDLANDS,ENGLAND

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 1979年 / 7卷 / 01期

关键词：

D O I：

10.1111/j.1365-2125.1979.tb00904.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. The serum profiles of chlorpropamide obtained following single doses of two tablet preparations and from a suspension formulation have been compared in healthy volunteers. The amounts of chlorpropamide absorbed from the three formulations were similar but the drug was absorbed more rapidly from the suspension than from either tablet formulation. There was a small but therapeutically insignificant difference in the rate of absorption of the drug from the two tablets. 2. Changes in blood glucose concentrations were found to be related to the drug serum profile characteristics of the formulations. 1979 The British Pharmacological Society

引用

页码：101 / 105

页数：5

共 11 条

[1] THE CORRELATION BETWEEN ORAL DOSAGE, BLOOD LEVELS, AND CLINICAL AND METABOLIC ACTIVITY OF CHLORPROPAMIDE IN THE TREATMENT OF DIABETES MELLITUS [J].

BEASER, SB .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1959, 74 (03) :701-708

[2] BLOOD LEVELS OF CHLORPROPAMIDE IN NORMAL MEN FOLLOWING CHRONIC ADMINISTRATION [J].

CARLOZZI, M ;

IEZZONI, DG ;

SILVER, L .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1959, 74 (03) :788-793

[3]

DUNCAN DB, 1955, BIOMETRICS, V2, P1

[4] A LABORATORY AND CLINICAL STUDY OF CHLORPROPAMIDE IN AMBULATORY DIABETICS [J].

HANDELSMAN, MB ;

LEVITT, L ;

CALABRETTA, MF .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1959, 74 (03) :632-642

[5] METABOLIC STUDIES OF CHLORPROPAMIDE IN NORMAL MEN AND IN DIABETIC SUBJECTS [J].

KNAUFF, RE ;

FAJANS, SS ;

RAMIREZ, E ;

CONN, JW .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1959, 74 (03) :603-617

[6] BIOAVAILABILITY IN MAN OF MARKETED BRANDS OF CHLORPROPAMIDE [J].

MONRO, AM ;

WELLING, PG .

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1974, 7 (01) :47-49

[7]

TAYLOR JA, 1972, CLIN PHARMACOL THER, V13, P710

[8] PLASMA CONCENTRATIONS, BIOAVAILABILITY AND DISSOLUTION OF CHLORPROPAMIDE [J].

TAYLOR, T ;

ASSINDER, DF ;

CHASSEAUD, LF ;

BRADFORD, PM ;

BURTON, JS .

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1977, 11 (03) :207-212

[9]

Trinder P., 1969, ANNALS CLINICAL BIOC, V6, P24

[10] METABOLISM AND RELATIVE HYPOGLYCEMIC POTENCIES OF 4 SULFONYLUREAS IN MAN [J].

WEST, KM ;

JOHNSON, PC .

DIABETES, 1960, 9 (06) :454-458

← 1 2 →