TRANSPORT MODELS FOR CHEMOTACTIC CELL-POPULATIONS BASED ON INDIVIDUAL CELL BEHAVIOR

被引：175

作者：

RIVERO, MA ^{[1
]}

TRANQUILLO, RT ^{[1
]}

BUETTNER, HM ^{[1
]}

LAUFFENBURGER, DA ^{[1
]}

机构：

[1] UNIV PENN,DEPT CHEM ENGN,PHILADELPHIA,PA 19104

来源：

CHEMICAL ENGINEERING SCIENCE | 1989年 / 44卷 / 12期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

Biological Materials--Cells - Mathematical Models;

D O I：

10.1016/0009-2509(89)85098-5

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

A simple, generalized transport equation for the migration of chemotactic cell populations is derived from a probabilistic model in one spatial dimension. This general equation is then made specific for the cases of flagellar bacteria and polymorphonuclear leukocytes, based on quantitative information concerning chemosensory movement behavior of individual cells of these types. The resulting specialized equations allow a priori estimation of the population transport coefficients (μ, the random motility coefficient, and χ, the chemotaxis coefficient) in terms of individual cell movement properties (such as speed, directional persistence time, and directional orientation bias). Thus, our model permits cell population migration to be related quantitatively to individual cell behavior. Examples of application of our models to experimental data are provided.

引用

页码：2881 / 2897

页数：17

共 44 条

[1] METHOD FOR MEASURING CHEMOTAXIS AND USE OF METHOD TO DETERMINE OPTIMUM CONDITIONS FOR CHEMOTAXIS BY ESCHERICHIA-COLI [J].