PROTECTIVE EFFECT OF INTERFERON AND POLYACRYLIC ACID IN NEWBORN MICE INFECTED WITH A LETHAL DOSE OF VESICULAR STOMATITIS VIRUS

被引：23

作者：

DECLERCQ, E

DESOMER, P

机构：

[1] Rega Institute for Medical Research, University of Leuven

来源：

LIFE SCIENCES PART 1 PHYSIOLOGY AND PHARMACOLOGY AND PART 2 BIOCHEMISTRY GENERAL AND MOLECULAR BIOLOGY | 1968年 / 7卷 / 17P1期

关键词：

D O I：

10.1016/0024-3205(68)90098-2

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Repeated intraperitoneal doses of preformed interferon and a single intraperitoneal injection of polyacrylic acid were shown to protect newborn mice from lethal infection with vesicular stomatitis virus. Both survival time and number of surviving mice were considerably increased by the injections. The antiviral activity of interferon and polyacrylic acid was inversely proportional to the dose of challenge virus. Nearly 100% of the mice treated with interferon survived a nearly 100% lethal infection (16 LD50). Polyacrylic acid diminished the mortality rate by 50 %. It is concluded that polyacrylic acid induces good host resistance to viruses and may be suitable in the prophylaxis of virus infections in vivo. © 1968.

引用

页码：925 / &

共 16 条

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[12]

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