STRATEGIES TO COMBAT MULTIDRUG RESISTANCE OF CANCER

被引：0

作者：

Bamburowicz-Klimkowska, Magdalena ^{[1
]}

Szutowski, Miroslaw M. ^{[1
]}

机构：

[1] Warszawski Uniwersytet Med, Katedra Zaklad Toksykol Wydzial Farmaceutyczn, Ul Banacha 1, PL-02097 Warsaw, Poland

来源：

BIULETYN WYDZIALU FARMACEUTYCZNEGO WARSZAWSKIEGO UNIWERSYTETU MEDYCZNEGO | 2012年 / 01期

关键词：

ATP-binding cassette [ABC] transporters; P-glycoprotein; multidrug resistance; nanoparticles;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Multidrug resistance (MDR) is a major impediment to the success of cancer chemotherapy. Significant progress in the understanding of MDR came with the identification of MDR P-glycoprotein and other transporters whose overexpression was observed in some types of cancer cells. In addition, the MDR phenomenon has also become associated with other mechanisms, such as inhibition of apoptosis of cancer cells. Several strategies of combating MDR are described here. However, their clinical success has been limited, largely due to efficacy and/or safety issues. These issues can be resolved by the use of nanotechnology. Nanoparticles have the potential to improve the therapeutic index of currently available drugs by increasing drug efficacy, reducing their toxicity, and helping to achieve a therapeutically relevant steady-state level of the drug over extended periods of time. Nanoparticles may also improve the solubility and stability of the drug.

引用

页码：1 / 8

页数：8

共 74 条

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