ISOLATION AND STRUCTURE ELUCIDATION OF 34-SULFATOBASTADIN-13, AN INHIBITOR OF THE ENDOTHELIN A RECEPTOR, FROM A MARINE SPONGE OF THE GENUS IANTHELLA

被引：35

作者：

GULAVITA, NK ^{[1
]}

WRIGHT, AE ^{[1
]}

MCCARTHY, PJ ^{[1
]}

POMPONI, SA ^{[1
]}

KELLYBORGES, M ^{[1
]}

CHIN, M ^{[1
]}

SILLS, MA ^{[1
]}

机构：

[1] CIBA GEIGY CORP,RES DEPT,SUMMIT,NJ 07901

来源：

JOURNAL OF NATURAL PRODUCTS | 1993年 / 56卷 / 09期

关键词：

D O I：

10.1021/np50099a026

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

34-Sulfatobastadin 13 [1] was isolated from the sponge lanthella sp. Its structure was elucidated by nmr techniques and chemical transformation to bastadin 13 [2]. Compound 1 weakly inhibited binding to the endothelin A receptor (ET(A)), while compound 2 inhibited growth of Bacillus subtilis.

引用

页码：1613 / 1617

页数：5

共 16 条

[1]

BUTLER MS, 1991, AUST J CHEM, V4, P296

[2] A NEW BASTADIN FROM THE SPONGE PSAMMAPLYSILLA-PURPUREA [J].