BLOCKADE OF DELTA-OPIOID RECEPTORS IN THE NUCLEUS-ACCUMBENS PREVENTS ETHANOL-INDUCED STIMULATION OF DOPAMINE RELEASE

被引：107

作者：

ACQUAS, E ^{[1
]}

MELONI, M ^{[1
]}

DICHIARA, G ^{[1
]}

机构：

[1] UNIV CAGLIARI,DEPT TOXICOL,VIALE A DIAZ 182,I-09126 CAGLIARI,ITALY

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1993年 / 230卷 / 02期

关键词：

DELTA-OPIOID RECEPTORS; DOPAMINE; ETHANOL;

D O I：

10.1016/0014-2999(93)90809-V

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Naltrindole, a specific delta-opioid antagonist, infused by reverse dialysis in the nucleus accumbens of freely moving rats completely prevented the increase in extracellular dopamine concentrations elicited in the nucleus accumbens by ethanol (1.0 g/kg i.p.) as well as by the delta-opioid receptor agonist [D-Ala2]deltorphin II (50 muM), also perfused by reverse dialysis, but not by cocaine (15 mg/kg s.c.). The results provide in vivo evidence for a critical role of delta-opioid receptors in the dopamine-releasing properties of ethanol in vivo.

引用

页码：239 / 241

页数：3

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