SYNTHESIS OF SOME NEW PYRIDO[3',2'4,5]THIENO[3,2-D]1,2,3-TRIAZINES WITH ANTIANAPHYLACTIC ACTIVITY

被引：0

作者：

WAGNER, G ^{[1
]}

LEISTNER, S ^{[1
]}

VIEWEG, H ^{[1
]}

KRASSELT, U ^{[1
]}

PRANTZ, J ^{[1
]}

机构：

[1] UNIV LEIPZIG,FACHBEREICH BIOWISSENSCH,LEIPZIG,GERMANY

来源：

PHARMAZIE | 1993年 / 48卷 / 07期

关键词：

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Some new pyrido[3',2':4,5]thieno[3,2-d]1,2,3-triazine-4(3H)-ones (C) were synthesized from 2-thioxo-1,2-dihydro-3-carbonitriles (A) via the 3-amino-thieno[2,3-b]pyridine-2-carboxamides (B). Substances of structure A were converted to 3-amino-thieno[2,3-b]pyridine-2-carbonitriles (G) which yielded the desired 4-amino substituted compounds I via the tricyclic 4-chloro-pyri-do[3',2':4:5]thieno[3,2-d]1,2,3-triazines (H) by the reaction with N-nucleophiles. Some of the investigated compounds showed a respectable antianaphylactic activity.

引用

页码：514 / 518

页数：5

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