CHARACTERIZATION OF IMMATURE CD4+CD8-CD3- THYMOCYTES

被引：33
|
作者：
HUGO, P
WAANDERS, GA
SCOLLAY, R
PETRIE, HT
BOYD, RL
机构：
[1] MONASH UNIV, SCH MED, DEPT PATHOL & IMMUNOL, CLAYTON, VIC 3168, AUSTRALIA
[2] ROYAL MELBOURNE HOSP, WALTER & ELIZA HALL INST MED RES, PARKVILLE, VIC 3050, AUSTRALIA
来源：
EUROPEAN JOURNAL OF IMMUNOLOGY | 1991年 / 21卷 / 03期
关键词：
D O I：
10.1002/eji.1830210346
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Previously we have described (Hugo, P. et al., Int. Immunol. 1990. 2: 209) an immature CD4+CD8-CD3- thymocyte subset which is thought to be the counterpart of the CD4-CD8+CD3- subset. In this study we show that the ontogeny of these two subsets is parallel in fetal thymic organ culture. Extensive phenotypic characterization of CD4+CD8-CD3- cells reveals that they closely resemble CD4-CD8+CD3- thymocytes being: HSA(high), Thy-1high, interleukin 2 receptor alpha chain negative, CD44-, H-2K +/-, CD5low, MEL-14low/intermediate, CD2+, LFA-1+ and MTS 35+. Finally, we show that the proportion of CD4+CD8-CD3- thymocytes is highly variable between mouse strains.
引用
收藏
页码：835 / 838
页数：4
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