SUICIDE INHIBITION OF MONOAMINE OXIDASE-A AND OXIDASE-B BY (-)-DEPRENYL - A COMPUTER-AIDED SOLUTION FOR DETERMINING INHIBITION SPECIFICITY

被引:3
|
作者
BATKE, J [1 ]
GAAL, J [1 ]
机构
[1] CHINOIN CHEM & PHARMACEUT WORKS LTD, BUDAPEST, HUNGARY
关键词
D O I
10.1016/0006-2952(93)90543-6
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
An analytical solution to the differential equations describing the kinetics of the suicide inhibition of a two-enzyme system has been derived and the modelling of suicide inhibition of the monoamine oxidases A and B (MAO A and B. EC 1.4.3.4) by a quasi-selective agent, (-)-deprenyl, is presented as an example. A new parameter, the specificity index is defined and used in a model which describes the specific and non-specific binding of (-)-deprenyl to MAO B and MAO A, respectively. This type of analysis may be of therapeutic value by indicating optimal dosage of quasi-selective MAO B inhibitors for the treatment of Parkinson's disease.
引用
收藏
页码:597 / 602
页数:6
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