SUICIDE INHIBITION OF MONOAMINE OXIDASE-A AND OXIDASE-B BY (-)-DEPRENYL - A COMPUTER-AIDED SOLUTION FOR DETERMINING INHIBITION SPECIFICITY

被引：3

作者：

BATKE, J ^{[1
]}

GAAL, J ^{[1
]}

机构：

[1] CHINOIN CHEM & PHARMACEUT WORKS LTD, BUDAPEST, HUNGARY

来源：

BIOCHEMICAL PHARMACOLOGY | 1993年 / 46卷 / 04期

关键词：

D O I：

10.1016/0006-2952(93)90543-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

An analytical solution to the differential equations describing the kinetics of the suicide inhibition of a two-enzyme system has been derived and the modelling of suicide inhibition of the monoamine oxidases A and B (MAO A and B. EC 1.4.3.4) by a quasi-selective agent, (-)-deprenyl, is presented as an example. A new parameter, the specificity index is defined and used in a model which describes the specific and non-specific binding of (-)-deprenyl to MAO B and MAO A, respectively. This type of analysis may be of therapeutic value by indicating optimal dosage of quasi-selective MAO B inhibitors for the treatment of Parkinson's disease.

引用

页码：597 / 602

页数：6

共 18 条

[1]

DELLACORTE L, 1977, BIOCHEM PHARMACOL, V26, P407

[2] INTERACTIONS OF MONOAMINE-OXIDASE WITH SUBSTRATES AND INHIBITORS [J].