ADAPTATION AND MAJOR CHROMOSOMAL CHANGES IN POPULATIONS OF SACCHAROMYCES-CEREVISIAE

被引：104
作者：
ADAMS, J
PUSKASROZSA, S
SIMLAR, J
WILKE, CM
机构：
[1] Department of Biology, University of Michigan, Ann Arbor, 48109, MI
来源：
CURRENT GENETICS | 1992年 / 22卷 / 01期
关键词：
CHROMOSOME LENGTH VARIANTS; ADAPTATION; YEAST; CONTINUOUS CULTURE;
D O I：
10.1007/BF00351736
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Thirteen independent populations of Saccharomyces cerevisiae (nine haploid and four diploid) were maintained in continuous culture for up to approximately 1000 generations, with growth limited by the concentration of organic phosphates in medium buffered at pH 6. Analysis of clones isolated from these populations showed that a number (17) of large-scale chromosomal-length variants and rearrangements were present in the populations at their termination. Nine of the 16 yeast chromosomes were involved in such changes. Few of the changes could be explained by copy-number increases in the structural loci for acid phosphatase. Several considerations concerning the nature and frequency of the chromosome-length variants observed lead us to conclude that they are selectively advantageous.
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页码：13 / 19
页数：7
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