SEROTONERGIC INNERVATION OF THE DORSAL HORN OF RAT SPINAL-CORD - LIGHT AND ELECTRON-MICROSCOPIC IMMUNOCYTOCHEMICAL STUDY

被引：93

作者：

MARLIER, L ^{[1
]}

SANDILLON, F ^{[1
]}

POULAT, P ^{[1
]}

RAJAOFETRA, N ^{[1
]}

GEFFARD, M ^{[1
]}

PRIVAT, A ^{[1
]}

机构：

[1] CNRS,NEUROIMMUNOL LAB,F-33077 BORDEAUX,FRANCE

来源：

JOURNAL OF NEUROCYTOLOGY | 1991年 / 20卷 / 04期

关键词：

D O I：

10.1007/BF01235548

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The ultrastructure of serotonergic projections to the dorsal horn of the rat spinal cord has been investigated, using a highly specific polyclonal antiserum. The highest concentrations of immunoreactive profiles were found in lamina I and the outer part of lamina II (IIo). Intermediate concentrations were found in laminae III and IV, while the inner part of lamina II (IIi) was almost devoid of immunoreactivity. Whereas 60% of the profiles show at least one varicosity studded with synaptic vesicles, only one-fifth of the latter contributes to classical synapses, the remaining profiles being devoid of a facing postsynaptic density. The results are compared with those in the literature and our own results relative to other regions of the cord. It is concluded that the pauci-synaptic projections to the dorsal horn could correspond to a diffuse influence of serotonin, the targets for which are determined by the corresponding serotonergic receptors.

引用

页码：310 / 322

页数：13

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[1] MODIFICATION OF LUMBAR MOTONEURON EXCITABILITY BY STIMULATION OF A PUTATIVE 5-HYDROXYTRYPTAMINE PATHWAY [J].