NICOTINE REDUCES THE BINDING OF [H-3] MK-801 TO BRAIN MEMBRANES, BUT NOT VIA THE STIMULATION OF HIGH-AFFINITY NICOTINIC RECEPTORS

被引：24
作者：
COURT, JA
PIGGOTT, MA
PERRY, EK
机构：
[1] MRC Neurochemical Pathology Unit, Newcastle General Hospital, Newcastle upon Tyne
来源：
BRAIN RESEARCH | 1990年 / 524卷 / 02期
关键词：
Cerebral cortex; MK-801; binding; Nicotine; Nicotinic receptor; Rat;
D O I：
10.1016/0006-8993(90)90708-J
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Nicotine (10 and 100 μM) inhibited [3H]MK-801 binding to rat cerebral cortical membranes and this effect was not blocked by dihydro-β-erythroidine, (+)-tubocurarine or mecamylamine. Cytisine, muscarine, mecamylamine and (+)-tubocurarine also inhibited [3H]MK-801 binding. Neither raising the MK-801 concentration, nor the addition of n-methyl-D-aspartate (NMDA) receptor agonists altered the effects of nicotine. Hence this response is not mediated via high-affinity nicotinic receptor stimulation, competition for MK-801 binding sites or require NMDA receptor activation. © 1990.
引用
收藏
页码：319 / 321
页数：3
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