INVITRO AND INVIVO EVALUATION OF TRANSDERMAL IONTOPHORETIC DELIVERY OF HYDROMORPHONE

被引：57

作者：

PADMANABHAN, RV ^{[1
]}

PHIPPS, JB ^{[1
]}

LATTIN, G ^{[1
]}

SAWCHUK, RJ ^{[1
]}

机构：

[1] UNIV MINNESOTA,DEPT PHARMACEUT,MINNEAPOLIS,MN 55455

来源：

JOURNAL OF CONTROLLED RELEASE | 1990年 / 11卷 / 1-3期

关键词：

hydromorphone; in vivo studies; iontophoresis; narcotic; transdermal drug delivery;

D O I：

10.1016/0168-3659(90)90126-E

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The narcotic analgesic, hydromorphone, was delivered by constant-current iontophoresis from aqueous solution through excised pig and human skin and from a hydrogel formulation into domestic pigs. The delivery rate per unit current was found to be similar for both pig and human skin, with a value of 1.1 mg h-1 mA -1, even though the passive fluxes differed by a factor of six. The in vitro delivery rate through pig skin at a current density of 125 μA/cm2 was found to be independent of the concentration of hydromorphone in the donor solution over the range from 0.01 M to 0.8 M. No correlation was observed between the initial passive hydromorphone delivery rate through pig skin and the steady-state rate during iontophoresis. In addition, in vivo delivery of hydromorphone into domestic pigs was studied at currents of up to 1.2 mA for 12 hours. Delivery rates were determined from plasma hydromorphone concentrations and from residual drug analysis of spent patches. The delivery rate per unit current determined from the plasma concentration and residual assay data were 1.9 and 1.2 mgh-1 mA -1, respectively. © 1990.

引用

页码：123 / 135

页数：13

共 19 条

[1]

Sanderson, Caldwell, Hsiao, Dixon, Tuttle, Noninvasive delivery of a novel inotropic catecholamine: iontophoretic versus intravenous infusion in dogs, J. Pharm. Sci., 76, pp. 215-218, (1987)

[2]

Petelenz, Dzelzkalns, Stephen, Hare, Jacobson, Iontophoresis of morphine, Proceedings of the 39th Annual Conference on Engineering in Medicine and Biology, (1986)

[3]

Chien, Siddiqui, Sun, Shi, Liu, Transdermal iontophoretic delivery of therapeutic peptides/proteins. 1. Insulin, Biological Approaches to the Controlled Delivery of Drugs, 507, pp. 32-51, (1988)

[4]

Okabe, Yamaguchi, Kawai, New iontophoretic transdermal administration of the beta-blocker metroprolol, J. Controlled Release, 4, pp. 79-85, (1986)

[5]

Phipps, Untereker, Iontophoresis apparatus and methods of producing same, (1988)

[6]

Phipps, Padmanabhan, Lattin, Iontophoretic delivery of model inorganic and drug ions, J. Pharm. Sci., 78, pp. 365-369, (1989)

[7]

Bannon, Corish, Corrigan, Masterson, Iontophoretically induced trandermal delivery of salbutamol, Drug Dev.Ind. Pharm., 14, pp. 2151-2166, (1988)

[8]

Padmanabhan, Phipps, Lattin, Transdermal delivery of propranolol via iontophoresis, Proceedings of the 13th International Symposium on Controlled Release of Bioactive Materials, (1986)

[9]

Phipps, Padmanabhan, Gillespie, Sunram, Iontohoretic delivery of propranolol across excised rabbit, pig and human skins, Proceedings of the 13th International Symposium on Controlled Release of Bioactive Materials, (1986)

[10]

Phipps, Padmanabhan, Lattin, Transport of ionic species through skin, Solid State Ionics, 28-30, pp. 1778-1783, (1988)

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