PREVENTIVE TREATMENT OF MIGRAINE HEADACHE WITH A NEW ISOERGOLENYL DERIVATIVE

被引：5
作者：
HERRMANN, WM [1 ]
KRISTOF, M [1 ]
SASTREYHERNANDEZ, M [1 ]
机构：
[1] SCHERING AG, DEPT CLIN NEUROPSYCHOPHARMACOL, BERLIN, GERMANY
来源：
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 1978年 / 6卷 / 06期
关键词：
D O I：
10.1177/030006057800600611
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
In the present double-blind clinical trial an isoergolenyl derivative with periphal antiserotonin, central dopaminergic activity and a-increasing effect on the human EEG, lisuride hydrogen maleate, was tested against placebo in a six-month trial involving 240 patients. Lisuride in long-term administration significantly reduces the frequency of migraine attacks in comparison to placebo. Its advantages are good tolerance and minimal side-effects. It is therefore concluded that lisuride is a suitable and effective drug for the prevention of migraine. © 1978, SAGE Publications. All rights reserved.
引用
收藏
页码：476 / 482
页数：7
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