LIPASE INHIBITORS ABOLISH CONTRACTIONS AND CAUSE DEPOLARIZATION IN FROG SKELETAL-MUSCLE FIBERS

被引：5

作者：

BRUTON, JD

WESTERBLAD, H

LANNERGREN, J

机构：

[1] KAROLINSKA INST,DEPT PHYSIOL & PHARMACOL,S-17177 STOCKHOLM,SWEDEN

[2] CHINESE UNIV HONG KONG,DEPT PHYSIOL,SHA TIN,HONG KONG

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS | 1994年 / 1200卷 / 02期

关键词：

FATIGUE; BROMOPHENYLACYLBROMIDE; NORDIHYDROGUAIRETIC ACID; LIPASE INHIBITOR; (MUSCLE);

D O I：

10.1016/0304-4165(94)90139-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Single, intact frog muscle fibres were exposed to bromophenylacylbromide (BPB) or nordihydroguairetic acid (NDGA). Fibres first became unable to respond to electrical stimulation and then depolarized; this process was accelerated by repeated activation. In addition BPB, but not NDGA, eventually induced a contracture in the fibre. The contractile response to direct Ca-release from the sarcoplasmic reticulum by caffeine was unaffected by the drugs.

引用

页码：224 / 226

页数：3

共 14 条

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[4]

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