Use of microRNAs in directing therapy and evaluating treatment response in colorectal cancer

被引：1
|
作者：
da Silveira Andreoli, Silmara Cristiane [1 ]
Gasparini, Nina Jardim [1 ]
de Carvalho, Gisele Pereira [2 ]
Garicochea, Bernardo [3 ]
Pogue, Robert Edward [1 ]
de Andrade, Rosangela Vieira [1 ]
机构：
[1] Univ Catolica Brasilia, Brasilia, DF, Brazil
[2] Pontificia Univ Catolica Rio Grande do Sul, Porto Alegre, RS, Brazil
[3] Ctr Oncol Sirio Libanes, Sao Paulo, SP, Brazil
来源：
EINSTEIN-SAO PAULO | 2014年 / 12卷 / 02期
关键词：
MicroRNAs; Biological markers; Colorectal neoplasms/chemotherapy; Treatment outcome; Combined modality therapy;
D O I：
10.1590/S1679-45082014MD2839
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Colorectal cancer is the third most common cancer worldwide. Survival and prognosis depend on tumor stage upon diagnosis, and in more than 50% of cases, the tumor has already invaded adjacent tissues or metastasis has occurred. Aiming to improve diagnosis, clinical prognosis and treatment of patients with colorectal cancer, several studies have investigated microRNAs as molecular markers of the disease due to their potential regulatory functions on tumor suppressor genes and oncogenes. This review aimed to summarize the main topics related to the use of microRNAs in diagnosis, clinical prognosis and evaluating treatment response in colorectal cancer.
引用
收藏
页码：256 / 258
页数：3
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