It highlights the main issues that confronting the agriculture of the Republic of Moldova, the effectiveness of land use and quality of agricultural soils. Issues of sustainable use of agricultural land are: excessive parceling land; inappropriate usage; failure of protective measures; irresponsible human activity, which leading to changes in landscapes, ecosystems and environment. Inefficient usage of agricultural land led to soil degradation that has spread throughout the area. Misuse of land led to reduced productivity of landscape, lowering evaluation notes, increased the processes of erosion, dehumification, salinization, secondary soil compaction. The results of highlight problems concerning the efficient use of agricultural land and diminution of soil quality degradation factors were developed mitigation measures and protection of land in context of sustainable development