PROGRAMMED CELL-DEATH AND AIDS - FROM HYPOTHESIS TO EXPERIMENT

被引：138
作者：
AMEISEN, JC
机构：
[1] Jean Claude Ameisen is at the Unité INSERM U167-CNRS 624, Institut Pasteur, F-59019 Lille
来源：
IMMUNOLOGY TODAY | 1992年 / 13卷 / 10期
关键词：
D O I：
10.1016/0167-5699(92)90086-M
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Here, jean Claude Ameisen discusses new findings supporting the hypothesis that abnormal induction of programmed cell death (PCD) is relevant to AIDS pathogenesis. Recent evidence also suggests that the prevention of PCD is a factor in oncogenesis. Together, these ideas provide a framework for the reinterpretation of cell survival disorders in terms of PCD dysregulation, and suggest that in vivo control of cell signalling has wide-ranging therapeutic potential.
引用
收藏
页码：388 / 391
页数：4
相关论文
共 42 条
[1]  
AMEISEN JC, 1991, IMMUNOL TODAY, V12, P102
[2]  
AMEISEN JC, 1991, RETROVIRUSES HUMAN A, P19
[3]   A THEORY OF SELF-NONSELF DISCRIMINATION [J].
BRETSCHER, P ;
COHN, M .
SCIENCE, 1970, 169 (3950) :1042-+
[4]   A SUPERANTIGEN ENCODED IN THE OPEN READING FRAME OF THE 3' LONG TERMINAL REPEAT OF MOUSE MAMMARY-TUMOR VIRUS [J].
CHOI, YW ;
KAPPLER, JW ;
MARRACK, P .
NATURE, 1991, 350 (6315) :203-207
[5]   PARTICIPATION OF TYROSINE PHOSPHORYLATION IN THE CYTOPATHIC EFFECT OF HUMAN-IMMUNODEFICIENCY-VIRUS .1. [J].
COHEN, DI ;
TANI, Y ;
TIAN, H ;
BOONE, E ;
SAMELSON, LE ;
LANE, HC .
SCIENCE, 1992, 256 (5056) :542-545
[6]  
DUKE RC, 1986, LYMPHOKINE RES, V5, P289
[7]   DEATH AND THE CELL [J].
DUVALL, E ;
WYLLIE, AH .
IMMUNOLOGY TODAY, 1986, 7 (04) :115-119
[8]  
FINKEL T, IN PRESS J EXP MED
[9]   COMMON EPITOPE IN HUMAN IMMUNODEFICIENCY VIRUS (HIV) I-GP41 AND HLA CLASS-II ELICITS IMMUNOSUPPRESSIVE AUTOANTIBODIES CAPABLE OF CONTRIBUTING TO IMMUNE DYSFUNCTION IN HIV I-INFECTED INDIVIDUALS [J].
GOLDING, H ;
SHEARER, GM ;
HILLMAN, K ;
LUCAS, P ;
MANISCHEWITZ, J ;
ZAJAC, RA ;
CLERICI, M ;
GRESS, RE ;
BOSWELL, RN ;
GOLDING, B .
JOURNAL OF CLINICAL INVESTIGATION, 1989, 83 (04) :1430-1435
[10]  
GOUGEON ML, 1991, CR ACAD SCI III-VIE, V312, P529
12345