CYTOSTATIC EFFECT OF DIFFERENT STRAINS OF BACILLUS CALMETTE-GUERIN ON HUMAN BLADDER-CANCER CELLS-INVITRO ALONE AND IN COMBINATION WITH MITOMYCIN-C AND INTERFERON-ALPHA

被引：49

作者：

RAJALA, P

KAASINEN, E

RINTALA, E

JAUHIAINEN, K

NURMI, M

ALFTHAN, O

LAHDE, M

机构：

[1] UNIV HELSINKI,CENT HOSP,UROL CLIN,SF-00100 HELSINKI 10,FINLAND

[2] MIKKELI CENT HOSP,DEPT SURG,MIKKELI,FINLAND

[3] FARMOS GRP LTD,TURKU,FINLAND

来源：

UROLOGICAL RESEARCH | 1992年 / 20卷 / 03期

关键词：

BLADDER CANCER; BCG; INTERFERON; ALPHA; CYTOSTATIC ACTIVITY INVITRO;

D O I：

10.1007/BF00299720

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The cytostatic activity of five Bacillus Calmette-Guerin (BCG) strains (Pasteur, Evans, Tice, RIVM and Connaught) on human transitional cell cancer T24 cells was examined. A striking effect was noted even in 2-day cultures, and the effect was more pronounced when the cells were incubated for 5 days with different BCG strains alone. The concentrations needed were about the same as those used in clinical practice (10(9) colony-forming units of Pasteur strain in 100 ml buffered saline solution). Combination with mitomycin C or interferon-alpha-2b potentiated the cytostatic effect. A slight difference in cytostatic activity between different BCG strains was found.

引用

页码：215 / 217

页数：3

共 8 条

[1] INTRAVESICAL CYTOSTATICS - PH-DEPENDENCE OF ANTITUMOUR ACTIVITY [J].