SIMILARITY BETWEEN THE VASORELAXING ACTIVITY OF DINITROSYL IRON CYSTEINE COMPLEXES AND ENDOTHELIUM-DERIVED RELAXING FACTOR

被引：89
作者：
VEDERNIKOV, YP
MORDVINTCEV, PI
MALENKOVA, IV
VANIN, AF
机构：
[1] ACAD SCI USSR,INST CHEM PHYS,KOSYGIN ST 4,MOSCOW 117334,USSR
[2] ACAD SCI USSR,CARDIOL RES CTR,MOSCOW 117334,USSR
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 211卷 / 03期
关键词：
DINITROSYL IRON COMPLEXES (WITH CYSTEINE); EDRF (ENDOTHELIUM-DERIVED RELAXING FACTOR); NITRIC OXIDE (NO); VASORELAXATION;
D O I：
10.1016/0014-2999(92)90386-I
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Dinitrosyl iron complexes with cysteine (DNIC) induced a concentration-dependent relaxation of pre-contracted (norepinephrine; 10(-7) M) de-endothelialized ring segments of rat aorta. The vasodilator response was more similar to acetylcholine (ACh)-induced relaxation in intact aortic rings than to nitric oxide (NO)-induced relaxation. The time course of tone recovery after maximal concentrations (10(-5) M) of DNIC was similar to the time course of tone recovery after endothelium-dependent relaxation induced by ACh, whereas the restoration of tone after NO was much faster. Vessel tone was restored by oxyhemoglobin (10(-5) M) in all cases. The results suggest that DNIC with cysteine may function as endothelium-derived relaxing factor in the vessels.
引用
收藏
页码：313 / 317
页数：5
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