REMOVAL OF BENZYL-TYPE PROTECTING GROUPS FROM PEPTIDES BY CATALYTIC TRANSFER HYDROGENATION WITH FORMIC-ACID

被引：275

作者：

ELAMIN, B ^{[1
]}

ANANTHARAMAIAH, GM ^{[1
]}

ROYER, GP ^{[1
]}

MEANS, GE ^{[1
]}

机构：

[1] OHIO STATE UNIV,DEPT BIOCHEM,COLUMBUS,OH 43210

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1979年 / 44卷 / 19期

关键词：

D O I：

10.1021/jo01333a048

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Summary: Formic acid is shown to be a particularly effective hydrogen donor for the rapid removal of peptide benzyl and benzyloxycarbonyl protecting groups by catalytic transfer hydrogenation.Sir: Catalytic transfer hydrogenation has been shown to be a useful procedure for the removal of benzyl and benzyloxycarbonyl protecting groups in peptide synthesis.1-4 Good yields of deprotected products have been obtained under relatively mild conditionsusing both. © 1979, American Chemical Society. All rights reserved.

引用

页码：3442 / 3444

页数：3

共 15 条

[1]

ANANTHARAMAIAH GM, 1978, INDIAN J CHEM B, V16, P797

[2]

ANANTHARAMAIAH GM, 1977, J CHEM SOC P1, V5, P490

[3]

ANANTHARAMAIAH GM, 1977, 26TH C INT UN PUR AP, P1123

[4]

ANWER MK, 1978, SYNTHESIS-STUTTGART, P75