A TRANSGLUTAMINASE THAT CONVERTS INTERLEUKIN-2 INTO A FACTOR CYTOTOXIC TO OLIGODENDROCYTES

被引：127

作者：

EITAN, S ^{[1
]}

SCHWARTZ, M ^{[1
]}

机构：

[1] WEIZMANN INST SCI, DEPT NEUROBIOL, IL-76100 REHOVOT, ISRAEL

来源：

SCIENCE | 1993年 / 261卷 / 5117期

关键词：

D O I：

10.1126/science.8100369

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Regenerating optic nerves from fish produce a factor that is cytotoxic to oligodendrocytes. The cytotoxic factor is recognized by antibodies to interleukin-2 (IL-2) and has the apparent molecular size of a dimer of IL-2. An enzyme, identified as a nerve transglutaminase, was purified from regenerating optic nerves of fish and was found to catalyze dimerization of human IL-2. The dimerized IL-2, unlike monomeric IL-2, is cytotoxic to oligodendrocytes from rat brain in culture. The results suggest that posttranslational modification of a cytokine can alter its activity. Under conditions in which oligodendrocytes inhibit neuronal regeneration, dimerization of IL-2 might provide a mechanism to permit nerve growth.

引用

页码：106 / 108

页数：3

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