EFFECT OF DOMOIC ACID ON METABOLISM OF 5-HYDROXYTRYPTAMINE IN RAT-BRAIN

被引：11
|
作者：
ARIAS, B [1 ]
ARUFE, M [1 ]
ALFONSO, M [1 ]
DURAN, R [1 ]
机构：
[1] UNIV VIGO,FAC CIENCIAS,DEPT BIOL FUNDAMENTAL,E-36200 VIGO,SPAIN
来源：
NEUROCHEMICAL RESEARCH | 1995年 / 20卷 / 04期
关键词：
DOMOIC ACID; SEROTONIN; RAT BRAIN;
D O I：
10.1007/BF00973094
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Domoic acid (Dom) is a neurotoxic secondary amino acid that interacts with the glutamate receptors, producing neurological problems. In the present work, we study the effects of Dom on the levels of serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) in discrete rat brain regions. The effects of Dom on the brain metabolism of serotonin are also discussed in this paper. Dom stimulates the rat brain serotoninergic system, increasing differentially the synthesis and the catabolism of 5-HT and the elimination of 5-HIAA.
引用
收藏
页码：401 / 404
页数：4
相关论文
共 50 条
12345