IMPACT OF DOSING SCHEDULE UPON SUPPRESSION OF A RETROVIRUS IN A MURINE MODEL OF AIDS ENCEPHALOPATHY

被引：7
作者：
BILELLO, JA
EISEMAN, JL
STANDIFORD, HC
DRUSANO, GL
机构：
[1] UNIV MARYLAND, SCH MED, DEPT MED, DEPT MICROBIOL & IMMUNOL, BALTIMORE, MD 21201 USA
[2] UNIV MARYLAND, SCH MED, DEPT MED, CTR CANC, BALTIMORE, MD 21201 USA
[3] BALTIMORE VA MED CTR, BALTIMORE, MD 21201 USA
[4] UNIV MARYLAND, SCH MED, DEPT MED, BALTIMORE, MD 21201 USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1994年 / 38卷 / 03期
关键词：
D O I：
10.1128/AAC.38.3.628
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We studied the impact of zidovudine (AZT) in Cas-Br-M murine leukemia virus-infected NFS-N mice after administration by once-daily bolus or continuous infusion. While higher peak concentrations of AZT were achieved by once-daily dosing, continuous AZT infusion at 25 mu g/h maintained levels >1 mu M in plasma and >0.2 mu M in the brain. Continuous infusion provided significantly better viral inhibition, even though total doses were only one-third that of the once-daily therapy group.
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收藏
页码：628 / 631
页数：4
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