SPECIES-DIFFERENCES IN THE CARDIOVASCULAR-RESPONSES TO HISTAMINE H-3 RECEPTOR ACTIVATION

被引：34
作者：
MCLEOD, RL
GERTNER, SB
HEY, JA
机构：
[1] SCHERING PLOUGH CORP,RES INST,ALLERGY,KENILWORTH,NJ 07033
[2] UNIV MED & DENT NEW JERSEY,NEW JERSEY MED SCH,DEPT PHARMACOL & TOXICOL,NEWARK,NJ 07103
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1994年 / 259卷 / 02期
关键词：
HISTAMINE H-3 RECEPTOR; R-ALPHA-METHYLHISTAMINE; SPECIES DIFFERENCE; PRESYNAPTIC INHIBITION; THIOPERAMIDE;
D O I：
10.1016/0014-2999(94)90512-6
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Potential species differences in cardiovascular responses to histamine H-3 receptor activation were studied in the conscious guinea pig, rabbit, normotensive rat and the spontaneously hypertensive rat. R-alpha-Methylhistamine (100 mu g/kg i.v.) decreased blood pressure in both the guinea pig and the rabbit. In the guinea pig, R-alpha-methylhistamine decreased heart rate, whereas in the rabbit it produced a tachycardia. In the normotensive rat and spontaneously hypertensive rat, R-alpha-methylhistamine (100 mu g/kg i.v.) had no effect on blood pressure and heart rate. The cardiovascular action of R-alpha-methylhistaminn in the guinea pig and rabbit was blocked by pretreatment with thioperamide (1.0 mg/kg i.v.) but not by chlorpheniramine (0.3 mg/kg i.v.) or cimetidine (3.0 mg/kg i.v.), respectively. These results indicate species differences in cardiovascular responses to histamine H-3 receptor activation.
引用
收藏
页码：211 / 214
页数：4
相关论文
共 10 条
[1]   CARDIOVASCULAR EFFECTS OF R-ALPHA-METHYLHISTAMINE, A SELECTIVE HISTAMINE H-3 RECEPTOR AGONIST, IN RATS - LACK OF INVOLVEMENT OF HISTAMINE H-3 RECEPTORS [J].
HEGDE, SS ;
CHAN, P ;
EGLEN, RM .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1994, 251 (01) :43-51
[2]   INHIBITION OF SYMPATHETIC HYPERTENSIVE RESPONSES IN THE GUINEA-PIG BY PREJUNCTIONAL HISTAMINE H3-RECEPTORS [J].
HEY, JA ;
DELPRADO, M ;
EGAN, RW ;
KREUTNER, W ;
CHAPMAN, RW .
BRITISH JOURNAL OF PHARMACOLOGY, 1992, 107 (02) :347-351
[3]   (R)-ALPHA-METHYLHISTAMINE AUGMENTS NEURAL, CHOLINERGIC BRONCHOSPASM IN GUINEA-PIGS BY HISTAMINE-H1 RECEPTOR ACTIVATION [J].
HEY, JA ;
DELPRADO, M ;
EGAN, RW ;
KREUTNER, W ;
CHAPMAN, RW .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1992, 211 (03) :421-426
[4]   ACTIVATION OF HISTAMINE H3-RECEPTORS PRODUCES PRESYNAPTIC INHIBITION OF NEURALLY EVOKED CAT NICTITATING-MEMBRANE RESPONSES INVIVO [J].
KOSS, MC ;
HEY, JA .
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1992, 346 (02) :208-212
[5]  
LEVI R, 1982, PHARM HISTAMINE RECE, P236
[6]  
MALINOWSKA B, 1993, N-S ARCH PHARMACOL, V347, P55
[7]   H3 RECEPTOR-MEDIATED INHIBITION OF THE NEUROGENIC VASOPRESSOR RESPONSE IN PITHED RATS [J].
MALINOWSKA, B ;
SCHLICKER, E .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1991, 205 (03) :307-310
[8]   MODULATION OF CARDIOVASCULAR FUNCTION BY CENTRAL HISTAMINE H3 RECEPTORS IN CONSCIOUS GUINEA-PIGS [J].
MCLEOD, RL ;
GERTNER, SB ;
HEY, JA .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1991, 209 (1-2) :141-142
[9]   PRODUCTION BY R-ALPHA-METHYLHISTAMINE OF A HISTAMINE H-3 RECEPTOR-MEDIATED DECREASE IN BASAL VASCULAR-RESISTANCE IN GUINEA-PIGS [J].
MCLEOD, RL ;
GERTNER, SB ;
HEY, JA .
BRITISH JOURNAL OF PHARMACOLOGY, 1993, 110 (02) :553-558
[10]   INHIBITION OF NORADRENALINE RELEASE FROM THE SYMPATHETIC-NERVES OF THE HUMAN SAPHENOUS-VEIN BY PRESYNAPTIC HISTAMINE H-3 RECEPTORS [J].
MOLDERINGS, GJ ;
WEISSENBORN, G ;
SCHLICKER, E ;
LIKUNGU, J ;
GOTHERT, M .
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1992, 346 (01) :46-50
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