POLYURETHANE SURFACE MODIFICATION BY GRAFT-POLYMERIZATION OF ACRYLAMIDE FOR REDUCED PROTEIN ADSORPTION AND PLATELET-ADHESION

被引：97

作者：

FUJIMOTO, K ^{[1
]}

TADOKORO, H ^{[1
]}

UEDA, Y ^{[1
]}

IKADA, Y ^{[1
]}

机构：

[1] KYOTO UNIV,BIOMED ENGN RES CTR,53 KAWAHARA CHO,SAKYO KU,KYOTO 606,JAPAN

来源：

BIOMATERIALS | 1993年 / 14卷 / 06期

关键词：

SURFACE MODIFICATION; GRAFT POLYMERIZATION; PROTEIN ADSORPTION; PLATELET ADHESION;

D O I：

10.1016/0142-9612(93)90147-T

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Surface modification of polyurethane by glow-discharge treatment and subsequent graft polymerization of acrylamide was studied. The modified hydrophilic surfaces were characterized by the measurements of dynamic contact angle and zeta potentials and examined for protein adsorption behaviour and platelet adhesion. Data from in vitro and ex vivo experiments indicated a reduction of protein adsorption and platelet adhesion for the hydrophillic graft polymers, the extent of which was correlated to polymer graft density.

引用

页码：442 / 448

页数：7

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