BEHAVIORAL-EFFECTS OF MOUSE INTERFERON-ALPHA AND INTERFERON-GAMMA AND HUMAN INTERFERON-ALPHA IN MICE

被引：49
作者：
CRNIC, LS
SEGALL, MA
机构：
[1] University of Colorado School of Medicine, Denver
来源：
BRAIN RESEARCH | 1992年 / 590卷 / 1-2期
关键词：
MOUSE; SPECIES SPECIFICITY; INTERFERON-ALPHA; INTERFERON-GAMMA; MOTOR ACTIVITY; FOOD INTAKE;
D O I：
10.1016/0006-8993(92)91106-O
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Behavioral effects of murine interferon-alpha and -gamma were explored using a well-characterized system for detecting interferon effects. In addition, the effectiveness of human interferon-alpha was determined. Mouse gamma-interferon decreased activity and food-related behavior, effects that were similar to the effects of mouse alpha-interferon. Equivalent doses of the human preparation had little effect upon these measures in mice. Some common action of alpha- and gamma-interferon is likely responsible for the similar effects seen for the two molecules. Low effectiveness of the human preparation in mice was predicted due to the differences in receptors between species.
引用
收藏
页码：277 / 284
页数：8
相关论文
共 59 条
[11]   IMMUNE-RESPONSE PRODUCTS ALTER CNS ACTIVITY - INTERFERON MODULATES CENTRAL OPIOID FUNCTIONS [J].
DAFNY, N ;
LEE, JR ;
DOUGHERTY, PM .
JOURNAL OF NEUROSCIENCE RESEARCH, 1988, 19 (01) :130-139
[12]  
DAFNY N, 1983, NEUROTOXICOLOGY, V4, P235
[13]   ALTERATION OF MORPHINE WITHDRAWAL TO NALOXONE BY INTERFERON-1 [J].
DAFNY, N ;
ZIELINKSI, M ;
REYESVAZQUEZ, C .
NEUROPEPTIDES, 1983, 3 (06) :453-463
[14]   MODIFICATION OF MORPHINE WITHDRAWAL BY INTERFERON [J].
DAFNY, N .
LIFE SCIENCES, 1983, 32 (04) :303-305
[15]   INTERACTIONS OF ALPHA-INTERFERON AND GAMMA-INTERFERON IN THE TRANSCRIPTIONAL REGULATION OF THE GENE ENCODING A GUANYLATE-BINDING PROTEIN [J].
DECKER, T ;
LEW, DJ ;
CHENG, YSE ;
LEVY, DE ;
DARNELL, JE .
EMBO JOURNAL, 1989, 8 (07) :2009-2014
[16]   BEHAVIORAL AND ECOG SPECTRUM CHANGES INDUCED BY INTRACEREBRAL INFUSION OF INTERFERONS AND INTERLEUKIN-2 IN RATS ARE ANTAGONIZED BY NALOXONE [J].
DESARRO, GB ;
MASUDA, Y ;
ASCIOTI, C ;
AUDINO, MG ;
NISTICO, G .
NEUROPHARMACOLOGY, 1990, 29 (02) :167-+
[17]   MECHANISMS OF FEVER INDUCED BY RECOMBINANT HUMAN INTERFERON [J].
DINARELLO, CA ;
BERNHEIM, HA ;
DUFF, GW ;
LE, HV ;
NAGABHUSHAN, TL ;
HAMILTON, NC ;
COCEANI, F .
JOURNAL OF CLINICAL INVESTIGATION, 1984, 74 (03) :906-913
[18]   DIFFERENTIAL MODIFICATION OF MORPHINE AND METHADONE DEPENDENCE BY INTERFERON-ALPHA [J].
DOUGHERTY, PM ;
PEARL, J ;
KRAJEWSKI, KJ ;
PELLIS, NR ;
DAFNY, N .
NEUROPHARMACOLOGY, 1987, 26 (11) :1595-1600
[19]   OPIATE ANTINOCICEPTION IS ALTERED BY IMMUNEMODIFICATION - THE EFFECT OF INTERFERON, CYCLOSPORINE AND RADIATION-INDUCED IMMUNE SUPPRESSION UPON ACUTE AND LONG-TERM MORPHINE ACTIVITY [J].
DOUGHERTY, PM ;
ARONOWSKI, J ;
SAMORAJSKI, T ;
DAFNY, N .
BRAIN RESEARCH, 1986, 385 (02) :401-404
[20]  
DUNN AJ, IN PRESS BRAIN BEHAV
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