ANIMAL-EXPERIMENTS ON THE ALLERGENICITY OF D-LIMONENE - THE CITRUS SOLVENT

被引：57

作者：

KARLBERG, AT ^{[1
]}

BOMAN, A ^{[1
]}

MELIN, B ^{[1
]}

机构：

[1] NATL BOARD OCCUPAT SAFETY & HLTH, ORGAN CHEM SECT, S-17184 SOLNA, SWEDEN

来源：

ANNALS OF OCCUPATIONAL HYGIENE | 1991年 / 35卷 / 04期

关键词：

D O I：

10.1093/annhyg/35.4.419

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

With the increasing use of d-limonene as a substitute for chlorinated hydrocarbons. chlorofluorocarbons (CFC) and other organic solvents, a demand has arisen for more knowledge of the health effects of this substance. The aim of the present study was to investigate the allergenic effect of d-limonene on skin. The sensitizing potential of d-limonene and the influence of air exposure on its allergenicity were studied in guineapigs. d-Limonene of high purity gave no significant allergic reactions, while d-limonene exposed to air for 2 months sensitized the animals. Gas chromatographic analyses indicated that the content of limonene oxide in limonene increased with prolonged air exposure. It is concluded that allergenic compounds are formed from d-limonene upon prolonged air exposure. Products containing d-limonene should therefore be kept in cold storage in closed vessels. Manual handling should be avoided, or gloves worn, in order to reduce the risk of sensitization.

引用

页码：419 / 426

页数：8

共 25 条

[1]

ADAMS RU, 1990, OCCUPATIONAL SKIN DI, P587

[2] Citrus fruit dermatoses [J].

Beerman, H ;

Fonde, GH ;

Callaway, JL .

ARCHIVES OF DERMATOLOGY AND SYPHILOLOGY, 1938, 38 (02) :225-234

[3]

BIRMINGHAM DJ, 1951, AMA ARCH IND HYG OCC, V3, P57

[4] EXPERIENCES WITH FREUND COMPLETE ADJUVANT TEST (FCAT) WHEN SCREENING FOR CONTACT ALLERGENS IN COLOPHONY [J].

BOMAN, A ;

KARLBERG, AT ;

WAHLBERG, JE .

CONTACT DERMATITIS, 1988, 18 (01) :25-29

[5]

CALNAN CD, 1979, CONTACT DERMATITIS, V5, P123, DOI 10.1111/j.1600-0536.1979.tb04817.x

[6]

CRONIN E, 1980, CONTACT DERMATITIS, P532

[7]

DEGROOT AC, 1986, PATCH TESTING, P46

[8]

DEGROOT AC, 1988, THESIS STATE U GRONI, P9

[9]

FISHER AA, 1986, CONTACT DERMATITIS, P264

[10]

GILDEMEISTER E, 1960, ATHERISCHEN OLE, V3, P45

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