Ondansetron Compared with High-Dose Metoclopramide in Prophylaxis of Acute and Delayed Cisplatin-Induced Nausea and Vomiting - A Multicenter, Randomized, Double-Blind, Crossover Study

被引：274
|
作者：
Demulder, PHM [1 ]
Seynaeve, C
Vermorken, JB
Vanliessum, PA
Molsjevdevic, S
Allman, EL
Beranek, P
Verweij, J
机构：
[1] Univ Hosp Nijmegen, Dept Med, Div Med Oncol, POB 9101, NL-6500 HB Nijmegen, NETHERLANDS
[2] Free Univ Amsterdam Hosp, Amsterdam, NETHERLANDS
[3] Glaxo Grp Res Ltd, Greenford UB6 0HE, Middx, ENGLAND
[4] Rotterdam Canc Inst, Rotterdam, NETHERLANDS
[5] Maria Hosp, Tilburg, NETHERLANDS
来源：
ANNALS OF INTERNAL MEDICINE | 1990年 / 113卷 / 11期
关键词：
D O I：
10.7326/0003-4819-113-11-834
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Ondansetron is significantly more effective than metoclopramide in preventing acute nausea and vomiting. In the delayed phase, the results of both drugs were disappointing, although metoclopramide's effect on delayed nausea was superior. Patients preferred ondansetron.
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页码：834 / 840
页数：7
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