PNEUMOCYSTIS-CARINII PNEUMONIA TREATED WITH EFLORNITHINE IN AIDS PATIENTS RESISTANT TO CONVENTIONAL THERAPY

被引：22

作者：

SMITH, D ^{[1
]}

DAVIES, S ^{[1
]}

NELSON, M ^{[1
]}

YOULE, M ^{[1
]}

GLEESON, J ^{[1
]}

GAZZARD, B ^{[1
]}

机构：

[1] WESTMINSTER MED SCH & HOSP,DEAN RYLE ST,HORSEFERRY RD,LONDON SW1P 2AP,ENGLAND

来源：

AIDS | 1990年 / 4卷 / 10期

关键词：

AIDS; DFMO; eflornithine; pen tamidine; Pneumocystis carinii; pneumonia; sulphamethoxazole-trimethoprim; treatment;

D O I：

10.1097/00002030-199010000-00012

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Eflornithine (DFMO) was used to treat 31 AIDS patients with confirmed Pneumocystis carinii pneumonia who had clinically failed treatment with pentamidine, sulphamethoxazole-trimethoprim or both agents as their first-line therapy. Twenty-one of 31 (68%) responded to second-line treatment with 400 mg/kg per day of eflornithine. Five patients discontinued treatment because of bone marrow toxicity. Eflornithine appears to be a useful salvage therapy in patients failing first-line treatments.

引用

页码：1019 / 1021

页数：3

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