DISTRIBUTION OF DIAMINE OXIDASE AND IMIDAZOLE-N-METHYLTRANSFERASE ALONG GASTROINTESTINAL TRACT

被引：43

作者：

KIM, KS

BACKUS, B

HARRIS, M

ROURKE, P

机构：

[1] Department of Pharmacology, The George Washington University School of Medicine, Washington, DC

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY | 1969年 / 31卷 / 01期

关键词：

Canis familiaris; Cavia porcellus; diamine oxidase; digestion; Felis cattus; histamine; imidazole methyl transferase; intestine; Mus musculus; Oryctolagus cuniculus domesticus; Rattus rattus;

D O I：

10.1016/0010-406X(69)92174-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. 1. Gastrointestinal distribution of diamine oxidase (DAO), imidazole-N-methyl transferase (IMIT) and histamine was studied in six mammalian species. 2. 2. DAO was high in the small intestine, low in the large intestine with the exception of the dog and practically absent in the stomach. In general, herbivores have lower DAO than either omnivores or carnivores. 3. 3. IMT activity was present all along the gastrointestinal tract with the exception of the rat stomach. In dogs, IMT activity was higher in the pyloric gland area than in the oxyntic gland area but the reverse was found in rabbits and guinea pigs. 4. 4. Germ-free rats showed similar DAO and IMT activity distribution in the small intestine as normal rats. © 1969.

引用

页码：137 / &

共 20 条

[1]

BEAVEN MA, 1967, FED PROC, V26, P233

[2]

BEST CH, 1930, AM J PHYSIOL, V70, P349

[3]

BROWN DD, 1959, J BIOL CHEM, V234, P2948

[4]

CODE CF, 1965, FED PROC, V24, P1311

[5] ABSORPTION OF HISTAMINE FROM GASTROINTESTINAL TRACT OF DOGS IN VIVO [J].

DUNCAN, JGC ;

WATON, NG .

JOURNAL OF PHYSIOLOGY-LONDON, 1968, 198 (03) :505-&

[6]

ERJAVEC F, 1966, Pharmacologist, V8, P186

[7]

GROSSMAN MI, 1952, J PHARMACOL EXP THER, V104, P277

[8] MOBILIZATION + FORMATION OF HISTAMINE IN GASTRIC MUCOSA AS RELATED TO ACID SECRETION [J].

KAHLSON, G ;

ROSENGREN, E ;

THUNBERG, R ;

SVAHN, D .

JOURNAL OF PHYSIOLOGY-LONDON, 1964, 174 (03) :400-+

[9]

KIM KS, 1963, J PHARMACOL EXP THER, V141, P321

[10] SEX DIFFERENCE IN HISTAMINE METABOLISM IN RATS [J].

KIM, KS .

AMERICAN JOURNAL OF PHYSIOLOGY, 1959, 197 (06) :1258-1260

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