Epithelial ovarian cancer - more data, more questions?

被引：0

作者：

Aust, Stefanie ^{[1
]}

Pils, Dietmar ^{[1
]}

机构：

[1] Med Univ Vienna, Comprehens Canc Ctr, Dept Obstet & Gynecol, Mol Oncol Grp, Wahringer Gurtel 18-20, A-1090 Vienna, Austria

来源：

WIENER MEDIZINISCHE WOCHENSCHRIFT | 2014年 / 164卷 / 21-22期

关键词：

Ovarian cancer; Prognosis; Peritoneal carcinomatosis; Targeted therapy; Tumor; Spread;

D O I：

10.1007/s10354-014-0323-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This review provides an overview of latest insights in epithelial ovarian cancer biology. The current understanding of the origin and the complex heterogeneity are depicted, followed by an introduction to the latest therapeutic approaches. The role of the tumor microenvironment, the high potential to disseminate within the peritoneal cavity, and new molecular biological findings are summarized.

引用

页码：479 / 486

页数：8

共 49 条

[1] Ambivalent role of pFAK-Y397 in serous ovarian cancer- a study of the OVCAD consortium [J].

Aust, Stefanie ;

Auer, Katharina ;

Bachmayr-Heyda, Anna ;

Denkert, Carsten ;

Sehouli, Jalid ;

Braicu, Ioana ;

Mahner, Sven ;

Lambrechts, Sandrina ;

Vergote, Ignace ;

Grimm, Christoph ;

Horvat, Reinhard ;

Castillo-Tong, Dan Cacsire ;

Zeillinger, Robert ;

Pils, Dietmar .

MOLECULAR CANCER, 2014, 13

[2] Determination of Tumor-infiltrating CD8+ Lymphocytes in Human Ovarian Cancer [J].

Aust, Stefanie ;

Bachmayr-Heyda, Anna ;

Pils, Dietmar ;

Zhao, Lijun ;

Tong, Weimin ;

Berger, Astrid ;

Fogel, Mina ;

Thalhammer, Theresa ;

Sehouli, Jalid ;

Horvat, Reinhard ;

Zeillinger, Robert ;

Castillo-Tong, Dan C. .

INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY, 2013, 32 (03) :269-276

[3] Role of TRAP1 and estrogen receptor alpha in patients with ovarian cancer -A study of the OVCAD consortium [J].

Aust, Stefanie ;

Bachmayr-Heyda, Anna ;

Pateisky, Petra ;

Tong, Dan ;

Darb-Esfahani, Silvia ;

Denkert, Carsten ;

Chekerov, Radoslav ;

Sehouli, Jalid ;

Mahner, Sven ;

Van Gorp, Toon ;

Vergote, Ignace ;

Speiser, Paul ;

Horvat, Reinhard ;

Zeillinger, Robert ;

Pils, Dietmar .

MOLECULAR CANCER, 2012, 11

[4] Prognostic impact of tumor infiltrating CD8+T cells in association with cell proliferation in ovarian cancer patients - a study of the OVCAD consortium [J].

Bachmayr-Heyda, Anna ;

Aust, Stefanie ;

Heinze, Georg ;

Polterauer, Stephan ;

Grimm, Christoph ;

Braicu, Elena Ioana ;

Sehouli, Jalid ;

Lambrechts, Sandrina ;

Vergote, Ignace ;

Mahner, Sven ;

Pils, Dietmar ;

Schuster, Eva ;

Thalhammer, Theresia ;

Horvat, Reinhard ;

Denkert, Carsten ;

Zeillinger, Robert ;

Castillo-Tong, Dan Cacsire .

BMC CANCER, 2013, 13

[5] Exposure of fallopian tube epithelium to follicular fluid mimics carcinogenic changes in precursor lesions of serous papillary carcinoma [J].

Bahar-Shany, K. ;

Brand, H. ;

Sapoznik, S. ;

Jacob-Hirsch, J. ;

Yung, Y. ;

Korach, J. ;

Perri, T. ;

Cohen, Y. ;

Hourvitz, A. ;

Levanon, K. .

GYNECOLOGIC ONCOLOGY, 2014, 132 (02) :322-327

[6] Integrated genomic analyses of ovarian carcinoma [J].

Bell, D. ;

Berchuck, A. ;

Birrer, M. ;

Chien, J. ;

Cramer, D. W. ;

Dao, F. ;

Dhir, R. ;

DiSaia, P. ;

Gabra, H. ;

Glenn, P. ;

Godwin, A. K. ;

Gross, J. ;

Hartmann, L. ;

Huang, M. ;

Huntsman, D. G. ;

Iacocca, M. ;

Imielinski, M. ;

Kalloger, S. ;

Karlan, B. Y. ;

Levine, D. A. ;

Mills, G. B. ;

Morrison, C. ;

Mutch, D. ;

Olvera, N. ;

Orsulic, S. ;

Park, K. ;

Petrelli, N. ;

Rabeno, B. ;

Rader, J. S. ;

Sikic, B. I. ;

Smith-McCune, K. ;

Sood, A. K. ;

Bowtell, D. ;

Penny, R. ;

Testa, J. R. ;

Chang, K. ;

Dinh, H. H. ;

Drummond, J. A. ;

Fowler, G. ;

Gunaratne, P. ;

Hawes, A. C. ;

Kovar, C. L. ;

Lewis, L. R. ;

Morgan, M. B. ;

Newsham, I. F. ;

Santibanez, J. ;

Reid, J. G. ;

Trevino, L. R. ;

Wu, Y. -Q. ;

Wang, M. .

NATURE, 2011, 474 (7353) :609-615

[7]

BLAUSTEIN A, 1984, INT J GYNECOL PATHOL, V3, P361

[8] Incorporation of Bevacizumab in the Primary Treatment of Ovarian Cancer [J].

Burger, Robert A. ;

Brady, Mark F. ;

Bookman, Michael A. ;

Fleming, Gini F. ;

Monk, Bradley J. ;

Huang, Helen ;

Mannel, Robert S. ;

Homesley, Howard D. ;

Fowler, Jeffrey ;

Greer, Benjamin E. ;

Boente, Matthew ;

Birrer, Michael J. ;

Liang, Sharon X. .

NEW ENGLAND JOURNAL OF MEDICINE, 2011, 365 (26) :2473-2483

[9] Intraepithelial T cells and prognosis in ovarian carcinoma: novel associations with stage, tumor type, and BRCA1 loss [J].

Clarke, Blaise ;

Tinker, Anna V. ;

Lee, Cheng-Han ;

Subramanian, Subbaya ;

van de Rijn, Matt ;

Turbin, Dmitry ;

Kalloger, Steve ;

Han, Guangming ;

Ceballos, Kathy ;

Cadungog, Mark G. ;

Huntsman, David G. ;

Coukos, George ;

Gilks, C. Blake .

MODERN PATHOLOGY, 2009, 22 (03) :393-402

[10] The role of the fallopian tube in the origin of ovarian cancer [J].

Erickson, Britt K. ;

Conner, Michael G. ;

Landen, Charles N., Jr. .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2013, 209 (05) :409-414

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