CALCIUM SIGNALING AND CELL-PROLIFERATION

被引：450
作者：
BERRIDGE, MJ
机构：
[1] Babraham Institute Laboratory of Molecular Signalling, Department of Zoology, Cambridge, CB2 3EJ, Downing Street
来源：
BIOESSAYS | 1995年 / 17卷 / 06期
关键词：
D O I：
10.1002/bies.950170605
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The orderly sequence of events that constitutes the cell cycle is carefully regulated. A part of this regulation depends upon the ubiquitous calcium signalling system. Many growth factors utilize the messenger inositol trisphosphate (InsP(3)) to set up prolonged calcium signals, often organized in an oscillatory pattern. These repetitive calcium spikes require both the entry of external calcium and its release from internal stores. One function of this calcium signal is to activate the immediate early genes responsible for inducing resting cells (G(0)) to re-enter the cell cycle. It may also promote the initiation of DNA synthesis at the G(1)/S transition. Finally, calcium contributes to the completion of the cell cycle by stimulating events at mitosis. The role of calcium in cell proliferation is highlighted by the increasing number of anti-cancer therapies and immunosuppressant drugs directed towards this calcium signalling pathway.
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页码：491 / 500
页数：10
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